GXYLT2 (glucoside xylosyltransferase 2)

Gene Basic Information

Gene Basic Information

symbol
GXYLT2
locus group
protein-coding gene
location
3p13
gene_family
Glycosyltransferase family 8
alias symbol
-
alias name
None
entrez id
727936
ensembl gene id
ENSG00000172986
ucsc gene id
uc003dpg.4
refseq accession
NM_001080393
hgnc_id
HGNC:33383
approved reserved
2007-04-12

Chromosome Location

Chromosome Location

3p13

Gene Summary

Gene Summary

ChineseEnglish

GXYLT2 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).[supplied by OMIM, Mar 2010]

OMIM entry for GXYLT2     Wikipedia entry for GXYLT2

Gene Sequence

Gene Sequence

Nucleotide sequence of GXYLT2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MKLRSKAAAL LLLALAALLL ALLSLRAGRA EPPALPARPA
41SAPQRHPAPV PARWPGPGAL PGASPGVRRR RPPRPRPRAG
81 RRGAARLEK LARRPGEPRS FQAVLPPELW IHLAVVACGN
121RLEETLVMLK SAVLFSHRKI QFHIFTEDSL KPEFDKQLRQ
161W PDSYTKKF EHRIYPITFS VGNPQEWKKL FKPCAAQRLF
201LPVILKDVDS LLYVDTDVLF LRPVDDIWKL LRLFNSTQLA
241AM APEHEIP KIGWYSRFAR HPFYGSAGVN SGVMLMNLTR
281IRSTQFKNSM IPTGLAWEDM LYPLYQKYKN AITWGDQDLL
321NII FYFNPE CLYVFPCQWN YRPDHCMYGS NCREAEHEGV
361SVLHGNRGVY HDDKQPTFRA LYEAIRDFPF QDNLFQSMYY
401PLQL KFLET VHTLCGRIPQ VFLKQIEKTM KRAYEKHVII
441HVGPNQMH
Structure predicted by AlphaFold DB(UniProt: A0PJZ3). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of GXYLT2:           Showing partial SNPs
rs884766       rs884767       rs955546       rs1052278       rs1108154       rs1388276       rs1393584       rs1463904       rs1466676       rs1502755       rs1502756       rs1502760       rs1532190       rs1814746       rs1847202       rs1875624       rs1875625      

Gene Expression

Gene Expression

Tissue expression of GXYLT2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTTGATAAGCAGTTACGCCAG
59
TCCTGAGGGTTTCCAACAG
59
AGTTCAAGAACAGCATGATTCC
59
TGGCATTCTTGTACTTCTGGT
60
AGTTCAAGAACAGCATGATTCC
59
TGGCATTCTTGTACTTCTGGT
60
GAAGTACAAGAATGCCATCAC
57
ACATAGAGACACTCTGGGT
57
GAAGTACAAGAATGCCATCAC
57
ACATAGAGACACTCTGGGT
57
TTGATAAGCAGTTACGCCAG
58
TCCTGAGGGTTTCCAACAG
59
GATAAGCAGTTACGCCAGTG
59
TCCTGAGGGTTTCCAACAG
59
TACCCAGTTCAAGAACAGC
57
TTCTTGTACTTCTGGTACAGAG
57
TACCCAGTTCAAGAACAGC
57
TTCTTGTACTTCTGGTACAGAG
57

Gene Ontology

Subcellular localization of GXYLT2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for GXYLT2:

GO ID
Protein
Source DB
GO:0016021
A0PJZ3 (UniProtKB)
IEA
GO:0016266
A0PJZ3 (UniProtKB)
IDA
GO:0035252
A0PJZ3 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating GXYLT2:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Publications

Related Publications

XXYLT1 inhibits NOTCH1 activation in Jurkat cells while promoting cell proliferation.
Wang W, Saiki W, Tsukamoto Y, Uchiyama S, Kondo Y, Okajima T, Takeuchi H Nagoya J Med Sci IF: 0.9 2025-08-00
Prognostic Signature GXYLT2 Is Correlated with Immune Infiltration in Bladder Cancer.
Wu S, Qiu S, Chen W, Ding L, Wu L Dis Markers 2022-00-00
In vitro assays of orphan glycosyltransferases and their application to identify Notch xylosyltransferases.
Sethi Maya K, Buettner Falk F R, Ashikov Angel, Bakker Hans Methods Mol Biol 2014-01-10
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.
Sethi Maya K, Buettner Falk F R, Ashikov Angel, Krylov Vadim B, Takeuchi Hideyuki, Nifantiev Nikolay E, Haltiwanger Robert S, Gerardy-Schahn Rita, Bakker Hans J Biol Chem IF: 4.1 2012-03-15
Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats.
Sethi Maya K, Buettner Falk F R, Krylov Vadim B, Takeuchi Hideyuki, Nifantiev Nikolay E, Haltiwanger Robert S, Gerardy-Schahn Rita, Bakker Hans J Biol Chem IF: 4.1 2010-02-08

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