HCK (HCK proto-oncogene, Src family tyrosine kinase)

Gene Basic Information

Gene Basic Information

symbol:
HCK
locus group:
protein-coding gene
location:
20q11.21
gene_family:
SH2 domain containing
alias symbol:
JTK9
alias name:
None
entrez id:
3055
ensembl gene id:
ENSG00000101336
ucsc gene id:
uc061wdn.1
refseq accession:
NM_001172129
hgnc_id:
HGNC:4840
approved reserved:
1986-01-01

Chromosome Location

Chromosome Location

20q11.21

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is a member of the Src family of tyrosine kinases. It is expressed primarily in hematopoietic cells, especially those of myeloid and B-lymphoid lineages. It can help couple Fc receptor activation to the respiratory burst and may also play roles in neutrophil migration and degranulation. Multiple isoforms with different subcellular distributions are produced by alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. Provided by RefSeq, February 2010.

OMIM entry for HCK     Wikipedia entry for HCK

Gene Sequence

Gene Sequence

Nucleotide sequence of HCK:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT
41ETSASPHCPV YVPDPTSTIK PGPNSHNSNT PGIREAGSED
81 IIVVALYDY EAIHHEDLSF QKGDQMVVLE ESGEWWKARS
121LATRKEGYIP SNYVARVDSL ETEEWFFKGI SRKDAERQLL
161A PGNMLGSF MIRDSETTKG SYSLSVRDYD PRQGDTVKHY
201KIRTLDNGGF YISPRSTFST LQELVDHYKK GNDGLCQKLS
241VP CMSSKPQ KPWEKDAWEI PRESLKLEKK LGAGQFGEVW
281MATYNKHTKV AVKTMKPGSM SVEAFLAEAN VMKTLQHDKL
321VKL HAVVTK EPIYIITEFM AKGSLLDFLK SDEGSKQPLP
361KLIDFSAQIA EGMAFIEQRN YIHRDLRAAN ILVSASLVCK
401IADF GLARV IEDNEYTARE GAKFPIKWTA PEAINFGSFT
441IKSDVWSFGI LLMEIVTYGR IPYPGMSNPE VIRALERGYR
481MPRPE NCPE ELYNIMMRCW KNRPEERPTF EYIQSVLDDF
521YTATESQYQQ QP
结构预测来自 AlphaFold DB（UniProt: P08631），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of HCK:           Showing partial SNPs
rs173355       rs242598       rs242599       rs242600       rs242601       rs242602       rs242603       rs242604       rs242605       rs242606       rs242607       rs242608       rs242609       rs242610       rs242611       rs242612       rs242613      

Gene Expression

Gene Expression

Tissue expression of HCK:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59
CTAGTTCTAGAAAGTCAGTTTCCC
59
TTGCTTTGTTTGTCTGGGC
60
CTAGAAAGTCAGTTTCCCGG
58
GAACTTGGACTTCATGCACC
60
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59
TCAAGTCAGACGTCTGGTC
59
TTGACATCCCTGGGTAAGG
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
PML
HCK
Unknown
21993313
RARA
HCK
Unknown
21993313
SPI1
HCK
Unknown
21993313

Gene Ontology

Subcellular localization of HCK (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for HCK:

GO ID
Protein
Source DB
GO:0004715
H0Y3C5 (UniProtKB)
IEA
GO:0005524
H0Y3C5 (UniProtKB)
IEA
GO:0018108
H0Y3C5 (UniProtKB)
IEA
GO:0018108
H0Y3C5 (UniProtKB)
IEA
GO:0004715
J3KPD6 (UniProtKB)
IEA
GO:0005524
J3KPD6 (UniProtKB)
IEA
GO:0018108
J3KPD6 (UniProtKB)
IEA
GO:0018108
J3KPD6 (UniProtKB)
IEA
GO:0002522
P08631 (UniProtKB)
TAS
GO:0002758
P08631 (UniProtKB)
TAS
GO:0004713
P08631 (UniProtKB)
IMP
GO:0004713
P08631 (UniProtKB)
EXP
GO:0004713
P08631 (UniProtKB)
EXP
GO:0004715
P08631 (UniProtKB)
IBA
GO:0005102
P08631 (UniProtKB)
IBA
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005515
P08631 (UniProtKB)
IPI
GO:0005524
P08631 (UniProtKB)
IEA
GO:0005634
P08631 (UniProtKB)
IEA
GO:0005764
P08631 (UniProtKB)
IDA
GO:0005794
P08631 (UniProtKB)
IEA
GO:0005829
P08631 (UniProtKB)
TAS
GO:0005829
P08631 (UniProtKB)
TAS
GO:0005901
P08631 (UniProtKB)
IDA
GO:0005925
P08631 (UniProtKB)
IMP
GO:0006468
P08631 (UniProtKB)
TAS
GO:0006954
P08631 (UniProtKB)
IEA
GO:0007155
P08631 (UniProtKB)
TAS
GO:0007169
P08631 (UniProtKB)
IBA
GO:0007229
P08631 (UniProtKB)
TAS
GO:0007498
P08631 (UniProtKB)
TAS
GO:0008284
P08631 (UniProtKB)
IMP
GO:0008360
P08631 (UniProtKB)
IMP
GO:0008360
P08631 (UniProtKB)
IMP
GO:0016032
P08631 (UniProtKB)
IEA
GO:0018108
P08631 (UniProtKB)
IMP
GO:0019221
P08631 (UniProtKB)
TAS
GO:0030133
P08631 (UniProtKB)
IEA
GO:0030154
P08631 (UniProtKB)
IBA
GO:0030838
P08631 (UniProtKB)
TAS
GO:0031234
P08631 (UniProtKB)
IMP
GO:0031663
P08631 (UniProtKB)
TAS
GO:0038083
P08631 (UniProtKB)
IBA
GO:0038096
P08631 (UniProtKB)
TAS
GO:0042995
P08631 (UniProtKB)
IEA
GO:0043066
P08631 (UniProtKB)
IMP
GO:0043299
P08631 (UniProtKB)
TAS
GO:0045728
P08631 (UniProtKB)
TAS
GO:0046777
P08631 (UniProtKB)
IMP
GO:0050690
P08631 (UniProtKB)
TAS
GO:0050727
P08631 (UniProtKB)
TAS
GO:0050764
P08631 (UniProtKB)
IMP
GO:0051090
P08631 (UniProtKB)
IMP
GO:0060333
P08631 (UniProtKB)
TAS
GO:0071801
P08631 (UniProtKB)
IDA
GO:2000251
P08631 (UniProtKB)
IMP
GO:2000251
P08631 (UniProtKB)
IDA
GO:0005884
P08631 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating HCK:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.12 1 0 CTD_human
Chronic Obstructive Airway Disease 0.005362824 2 0 BeFree_GAD_LHGDN
Multiple Myeloma 0.002995792 1 0 BeFree_LHGDN
HIV Infections 0.002909916 3 0 BeFree_GAD
Infection 0.00272435 1 0 LHGDN
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Idiopathic osteoarthritis 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree

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