HDHD5-AS1是一个长链非编码RNA（lncRNA）基因，位于人类染色体1p36.33区域，属于HDHD5基因的反义链转录本。它不编码蛋白质，但可能通过调控邻近基因HDHD5的表达或其他机制发挥生物学功能。HDHD5属于水解酶家族，其编码的蛋白质可能参与磷酸酯键的水解代谢过程，但HDHD5-AS1的具体功能尚未完全明确。研究表明，lncRNA通常通过表观遗传调控、转录干扰或作为miRNA海绵影响基因表达网络。HDHD5-AS1的异常表达可能与某些疾病相关，例如有研究发现它在结直肠癌组织中表达下调，提示其可能具有抑癌作用，但具体机制仍需进一步验证。若该基因过表达，可能通过调控HDHD5或其他靶基因影响细胞增殖或代谢途径；而表达降低则可能导致调控功能丧失，影响相关信号通路。目前关于HDHD5-AS1突变的研究较少，但lncRNA的突变或表达异常通常会影响其相互作用分子的功能。HDHD5属于HDHD（Haloacid Dehalogenase-like Hydrolase Domain）基因家族，该家族成员多具有水解酶活性，参与多种生物化学反应。由于HDHD5-AS1的研究尚处于早期阶段，其详细机制和临床意义仍需更多实验数据支持。

HDHD5-AS1 is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the human chromosome 1p36.33 region, serving as a regulatory counterpart to the neighboring HDHD5 gene, which encodes a member of the haloacid dehalogenase-like hydrolase domain (HDHD) family known for its role in phosphate ester bond hydrolysis. Although HDHD5-AS1 does not encode a protein, it likely exerts biological influence through mechanisms typical of lncRNAs, such as epigenetic modulation, transcriptional interference, or acting as a microRNA sponge to fine-tune the expression of HDHD5 and other targets within metabolic and signaling networks. Emerging evidence suggests that HDHD5-AS1 may function as a tumor suppressor, as its expression is notably downregulated in colorectal cancer tissues, implying that its loss could disrupt the regulation of cell proliferation and metabolic pathways, whereas its overexpression might restore or alter these homeostatic controls. While the specific molecular interactions and downstream effects of HDHD5-AS1 mutations remain under investigation, the gene’s role in maintaining cellular function is consistent with the broader hydrolytic activities of the HDHD family, and further research is required to fully elucidate its precise mechanistic contributions and clinical relevance in disease contexts.

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