HOOK1 (hook microtubule tethering protein 1)

Gene Basic Information

Gene Basic Information

symbol
HOOK1
locus group
protein-coding gene
location
1p32.1
gene_family
-
alias symbol
HK1
alias name
None
entrez id
51361
ensembl gene id
ENSG00000134709
ucsc gene id
uc001czo.3
refseq accession
NM_015888
hgnc_id
HGNC:19884
approved reserved
2003-11-25

Chromosome Location

Chromosome Location

1p32.1

Gene Summary

Gene Summary

ChineseEnglish

The HOOK1 gene encodes a member of the HOOK protein family, a conserved group of cytoplasmic adaptor proteins that serve as critical molecular bridges in intracellular trafficking. By leveraging its N-terminal microtubule-binding domain and C-terminal cargo-binding domain, HOOK1 facilitates the directional transport of vesicles along the microtubule network, specifically mediating the shuttling of cargo between the Golgi apparatus and endosomes to maintain the dynamic homeostasis of the endomembrane system. While HOOK family members share these structural motifs, HOOK1 is distinguished by its predominant expression in the nervous system, where it plays a pivotal role in axonal transport, synaptic vesicle dynamics, and the maintenance of synaptic function. Disruptions in HOOK1 function, whether through loss-of-function mutations that impair transport efficiency and synaptic plasticity or gain-of-function events that disrupt normal vesicular logistics, have been implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Beyond its neurological significance, emerging evidence suggests that HOOK1 also contributes to oncogenic processes by modulating cell division and migration, indicating a broader role in cellular physiology that extends to the regulation of cancer development.

OMIM entry for HOOK1     Wikipedia entry for HOOK1

Gene Sequence

Gene Sequence

Nucleotide sequence of HOOK1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MEETQPPPQP KLPLCDSLMI WLQTFNTASP CQDVKQLTSG
41VAMAQVLHQI DAAWFNESWL SRIKEDVGDN WRIKASNVKK
81 VLQGIMSYY HEFLGQQISE ALIPDLNQIT ECSDPVELGR
121LLQLILGCAI NCEKKQEHIQ NIMTLEESVQ HVVMTAIQEL
161M SKEILSSP PNDAVGELEQ QLKRALEELQ EALAEKEELR
201QRCEELDMQV TTLQDEKNSL VSENEMMNEK LDQLDGSFDD
241PN TVVAKKY FHAQLQLEQL QEENFRLEAA KDDYRVHCEE
281LEKQLIEFQH RNDELTSLAE ETRALKDEID VLRATSDKAN
321KLE STVEIY RQKLQDLNDL RKQVKTLQET NMMYMHNTVS
361LEEELKKANA ARTQLETYKR QVQDLHVKLS SESKRADTLA
401FEMK RLEEK HEALLKEKER LIEQRDTLKE TNEELRCSQV
441QQDHLNQTDA SATKSYENLA AEIMPVEYRE VFIRLQHENK
481MLRLQ QEGS ENERIEELQE QLEQKHRKMN ELETEQRLSK
521ERIRELQQQI EDLQKSLQEQ GSKSEGESSS KLKQKLEAHM
561EKLTEV HEE LQKKQELIED LQPDINQNVQ KINELEAALQ
601KKDEDMKAME ERYKMYLEKA RNVIKTLDPK LNPASAEIML
641LRKQLAE KE RRIEILESEC KVAKFRDYEE KLIVSAWYNK
681SLAFQKLGME SRLVSGGGAC SDTGACTPAR SFLAQQRHIT
721NTRRNLSV K VPATTSD
Structure predicted by AlphaFold DB(UniProt: Q9UJC3). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of HOOK1:           Showing partial SNPs
rs618716       rs629636       rs1051145       rs1933218       rs1933219       rs2025500       rs2147395       rs2235798       rs2294946       rs2294947       rs2294948       rs2294949       rs2294950       rs3754201       rs3754203       rs3754204       rs3767996      

Gene Expression

Gene Expression

Tissue expression of HOOK1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GTATTAGAGAATTGCAGCAGC
58
TGAGACGATTTACTTTCGCC
58
GCGTGGTATAATAAGAGTCTAGC
59
CTTCTGGTGTTGGTGATGTG
59
AGCTGCAGACATTCAATACTG
59
CATTACTGGCCTTTATTCTCCA
58
TCATGATCTGGCTGCAGAC
60
AGATTCGTTAAACCAAGCTGC
60
GAAGAATTGAGATTCTGGAGAGTG
59
ATACCACGCAGAAACAATGAG
59
GCGTGGTATAATAAGAGTCTAGC
59
CTTCTGGTGTTGGTGATGTG
59
AAACTGAGCAGAGGCTGAG
60
AGACTTGGAACCTTGTTCCT
59
ATGCAGCTTGGTTTAACGA
58
ACATTACTGGCCTTTATTCTCC
58
CTGAAGGCGAAAGTTCCAG
59
TGTAATTCTTCATGGACCTCTG
58
GAAGAATTGAGATTCTGGAGAGTG
59
TACCACGCAGAAACAATGAG
59

Gene Ontology

Subcellular localization of HOOK1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for HOOK1:

GO ID
Protein
Source DB
GO:0003779
Q9UJC3 (UniProtKB)
IEA
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005515
Q9UJC3 (UniProtKB)
IPI
GO:0005829
Q9UJC3 (UniProtKB)
IEA
GO:0005874
Q9UJC3 (UniProtKB)
IEA
GO:0007032
Q9UJC3 (UniProtKB)
IMP
GO:0007040
Q9UJC3 (UniProtKB)
IMP
GO:0007275
Q9UJC3 (UniProtKB)
IEA
GO:0007286
Q9UJC3 (UniProtKB)
IEA
GO:0008017
Q9UJC3 (UniProtKB)
IEA
GO:0008333
Q9UJC3 (UniProtKB)
IMP
GO:0015031
Q9UJC3 (UniProtKB)
IEA
GO:0042802
Q9UJC3 (UniProtKB)
IPI
GO:0045022
Q9UJC3 (UniProtKB)
IMP
GO:0070695
Q9UJC3 (UniProtKB)
IDA
GO:0030897
Q9UJC3 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating HOOK1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Tobacco Use Disorder 0.002367032 1 0 GAD
Juvenile Neuronal Ceroid Lipofuscinosis 0.000542884 2 0 BeFree

Related Publications

Related Publications

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Feng LL, Wang YT, Huang CF, Sun CY, Jun YL, Zhang L Zhongguo Shi Yan Xue Ye Xue Za Zhi 2026-06-00
<italic>HOOK1</italic> Gene Expression and DNA Methylation in Obesity and Related Cardiometabolic Traits.
Svensson SIA, Saeed S, Hoffmann A, Ghosh A, Wolfrum C, Dahl MB, Cayir A, Rønningen T, Bai B, Mala T, Kristinsson JA, Kovacs P, Blüher M, Valderhaug TG, Böttcher Y Obes Facts IF: 4.1 2026-00-00
LARS2 DNA methylation predicts the prognosis in colon cancer.
Fu Y, Xie W, Ren Q, Wu J, Long Y, Liu Y Sci Rep IF: 4.9 2025-07-22
A missense mutation in TCFL5 is associated with male infertility due to oligoasthenoteratozoospermia.
Yu K, Zhang W, Wang Y, Xiang M, Zheng N, Zhang J, Zha X, Duan Z, Wang F, Cao Y, Zhu F Mol Genet Genomics IF: 2.2 2025-07-25
Analysis of multiple programmed cell death-related prognostic genes and functional validations of necroptosis-associated genes in oesophageal squamous cell carcinoma.
Cao K, Zhu J, Lu M, Zhang J, Yang Y, Ling X, Zhang L, Qi C, Wei S, Zhang Y, Ma J EBioMedicine IF: 11.2 2024-01-00
Protein homeostasis maintained by HOOK1 levels promotes the tumorigenic and stemness properties of ovarian cancer cells through reticulum stress and autophagy.
Suárez-Martínez E, Piersma SR, Pham TV, Bijnsdorp IV, Jimenez CR, Carnero A J Exp Clin Cancer Res IF: 5.189 2024-05-29
ALK-Rearranged Renal Cell Carcinoma: A Multi-Institutional Study of 9 Cases With Expanding the Morphologic and Molecular Genetic Spectrum.
Zhao M, Yin X, Yang X, Gan H, Chen N, Duan G, Bai Y, Teng X, Xu J, Fang R, Wang S, Zhong S, Wang X, Teng L Mod Pathol IF: 6.6 2024-08-00

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