HPGDS (hematopoietic prostaglandin D synthase)

Gene Basic Information

Gene Basic Information

symbol
HPGDS
locus group
protein-coding gene
location
4q22.3
gene_family
Glutathione S-transferases
alias symbol
GSTS|PGDS|H-PGDS|PGD2|GSTS1-1|GSTS1
alias name
glutathione S-transferase sigma
entrez id
27306
ensembl gene id
ENSG00000163106
ucsc gene id
uc003hte.2
refseq accession
NM_014485
hgnc_id
HGNC:17890
approved reserved
2009-07-14

Chromosome Location

Chromosome Location

4q22.3

Gene Summary

Gene Summary

ChineseEnglish

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

OMIM entry for HPGDS     Wikipedia entry for HPGDS

Gene Sequence

Gene Sequence

Nucleotide sequence of HPGDS:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MPNYKLTYFN MRGRAEIIRY IFAYLDIQYE DHRIEQADWP
41EIKSTLPFGK IPILEVDGLT LHQSLAIARY LTKNTDLAGN
81 TEMEQCHVD AIVDTLDDFM SCFPWAEKKQ DVKEQMFNEL
121LTYNAPHLMQ DLDTYLGGRE WLIGNSVTWA DFYWEICSTT
161L LVFKPDLL DNHPRLVTLR KKVQAIPAVA NWIKRRPQTK
201L
Structure predicted by AlphaFold DB(UniProt: O60760). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of HPGDS:           Showing partial SNPs
rs724260       rs767657       rs901615       rs901616       rs1344612       rs1386531       rs1426575       rs1906238       rs2016476       rs2016483       rs2059605       rs2059606       rs2129595       rs2171381       rs2289186       rs2865351       rs2865352      

Gene Expression

Gene Expression

Tissue expression of HPGDS:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CAAATCAACTCTCCCATTTGG
58
CTTGCTATTGCTAGGCTCTG
59
CTTATTGGTAACTCTGTAACTTGGG
60
CAGGTCAGGCTTAAAGACCA
60
CAAATCAACTCTCCCATTTGG
58
CTTGCTATTGCTAGGCTCTG
59
CATATAAACCCAAGGCACAGTC
60
TGGTGCAATTCTGTGTTATGTC
60
GAAGTTGATGGACTTACTCTTCAC
60
TGTGTTTCCAGCCAAATCTG
59
GAAGTTGATGGACTTACTCTTCAC
60
TGTGTTTCCAGCCAAATCTG
59
TAATGCGCCTCATCTTATGC
59
GCCCAAGTTACAGAGTTACC
58
TCATATAAACCCAAGGCACAG
58
GGTGCAATTCTGTGTTATGTC
58
TTGGAAGTTGATGGACTTACTC
58
GTTTCCAGCCAAATCTGTG
57
CGCCTCATCTTATGCAAGAC
59
AGTCTGCCCAAGTTACAGAG
60

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
POU2F1
HPGDS
Unknown
10998423

Gene Ontology

Subcellular localization of HPGDS (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for HPGDS:

GO ID
Protein
Source DB
GO:0000287
O60760 (UniProtKB)
IDA
GO:0004364
O60760 (UniProtKB)
TAS
GO:0004667
O60760 (UniProtKB)
EXP
GO:0004667
O60760 (UniProtKB)
IDA
GO:0005509
O60760 (UniProtKB)
IDA
GO:0005515
O60760 (UniProtKB)
IPI
GO:0005515
O60760 (UniProtKB)
IPI
GO:0005515
O60760 (UniProtKB)
IPI
GO:0005737
O60760 (UniProtKB)
TAS
GO:0005829
O60760 (UniProtKB)
TAS
GO:0005829
O60760 (UniProtKB)
TAS
GO:0006693
O60760 (UniProtKB)
IDA
GO:0007165
O60760 (UniProtKB)
NAS
GO:0007626
O60760 (UniProtKB)
TAS
GO:0019371
O60760 (UniProtKB)
TAS
GO:0042803
O60760 (UniProtKB)
IPI
GO:1901687
O60760 (UniProtKB)
TAS
GO:2000255
O60760 (UniProtKB)
IEA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Testicular Germ Cell Tumor 0.240542884 2 3 BeFree_CTD_human_GWASCAT
Liver diseases 0.120271442 2 0 BeFree_CTD_human
Carcinoma of lung 0.017100838 63 0 BeFree
Malignant neoplasm of breast 0.016829396 62 7 BeFree
Breast Carcinoma 0.016557954 61 7 BeFree
Malignant neoplasm of lung 0.016557954 61 0 BeFree
Prostate carcinoma 0.016557954 61 1 BeFree
Malignant neoplasm of prostate 0.016286512 60 1 BeFree
Asthma 0.012486326 46 0 BeFree
Colorectal Cancer 0.012214884 45 2 BeFree

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