IER3-AS1 (IER3 antisense RNA 1)

Gene Basic Information

Gene Basic Information

symbol:
IER3-AS1
locus group:
non-coding RNA
location:
6p21.33
gene_family:
None
alias symbol:
None
alias name:
None
entrez id:
105379695
ensembl gene id:
ENSG00000272273
ucsc gene id:
None
refseq accession:
NR_149095
hgnc_id:
HGNC:53629
approved reserved:
2017-08-03

Chromosome Location

Chromosome Location

6p21.33

Gene Summary

Gene Summary

IER3-AS1是一个长链非编码RNA（lncRNA），位于人类染色体6p21.3区域，与IER3基因（立即早期反应基因3）相邻且反向转录。它属于非编码RNA家族，主要功能是通过调控邻近基因IER3的表达或其他信号通路来参与细胞应激反应、凋亡和炎症过程。IER3-AS1在多种癌症中表现出异常表达，例如在肝癌、胃癌和乳腺癌中可能作为肿瘤抑制因子或促癌因子发挥作用，具体取决于癌症类型和微环境。其过表达可能通过影响细胞周期或凋亡相关基因（如p53或NF-κB通路）促进肿瘤进展，而低表达可能导致细胞对应激的敏感性增加。IER3-AS1的突变或表达异常与癌症预后相关，例如在胃癌中高表达与不良预后相关。IER3基因家族（立即早期反应基因家族）的共性是对外界刺激（如辐射、细胞因子或应激）快速响应，参与细胞增殖、分化和凋亡的调控。IER3-AS1可能通过表观遗传调控（如启动子甲基化）或竞争性内源RNA（ceRNA）机制影响其他基因的功能。研究还发现它与免疫微环境调控相关，可能通过调节炎症因子影响肿瘤免疫逃逸。目前对其具体机制仍需进一步探索，但它在疾病诊断或治疗中的潜在价值已受到关注。

OMIM entry for IER3-AS1     Wikipedia entry for IER3-AS1

Gene Sequence

Gene Sequence

Nucleotide sequence of IER3-AS1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of IER3-AS1:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of IER3-AS1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of IER3-AS1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for IER3-AS1:

Related microRNA

Related microRNA

microRNAs potentially regulating IER3-AS1:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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