IL23R基因详情-基因数据库-基因云馆

IL23R (interleukin 23 receptor)

symbol:: IL23R
locus group:: protein-coding gene
location:: 1p31.3
gene_family:
alias symbol:: IL-23R
alias name:: None
entrez id:: 149233
ensembl gene id:: ENSG00000162594
ucsc gene id:: uc001ddo.4
refseq accession:: NM_144701
hgnc_id:: HGNC:19100
approved reserved:: 2004-10-18

1p31.3

IL23R基因编码白细胞介素23受体（Interleukin-23 receptor），属于I型细胞因子受体家族。该基因位于人类1号染色体上，其表达产物IL-23R是一种跨膜蛋白，主要表达于免疫细胞如Th17细胞、自然杀伤细胞、巨噬细胞和树突状细胞表面。IL-23R与IL-12Rβ1亚基共同组成功能性IL-23受体复合物，能够特异性结合细胞因子IL-23（由IL23A和IL12B亚基组成）。这个信号通路在获得性免疫和炎症反应中起关键作用，特别是促进Th17细胞的分化和维持，以及促炎细胞因子（如IL-17、IL-22）的产生。IL23R基因突变可能显著影响其功能，例如rs11209026（Arg381Gln）多态性可降低受体活性，减少IL-23信号传导，从而降低患自身免疫性疾病如银屑病、克罗恩病和强直性脊柱炎的风险。相反，该基因的过度激活可能导致Th17细胞异常增殖和过度炎症反应，与多种自身免疫性疾病的发生发展密切相关。IL23R属于IL-12受体家族，该家族成员均为I型细胞因子受体，具有共同的结构特征如细胞外免疫球蛋白样结构域和细胞因子受体同源结构域，主要参与调节免疫细胞活化和炎症反应。当IL23R表达下调时，可能导致免疫应答不足，增加感染风险；而过表达则可能引发过度炎症反应和自身免疫病理损伤。目前针对IL-23/IL-23R通路的生物制剂（如ustekinumab）已成功用于治疗银屑病等自身免疫性疾病。

中文English

由该基因编码的蛋白质是受体IL23A / IL23的一个亚基。与受体分子IL12RB1 / IL12Rbeta1该蛋白质对，并且两者都需要对IL23A信令。这与Janus激酶2蛋白联营组成（JAK2），并且还结合转录激活STAT3以配体依赖性。 [由RefSeq的，2008年7月提供]

OMIM数据库中对IL23R基因的介绍 Wikipedia数据库中对IL23R基因的介绍

IL23R基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT
41IFKMGMNISI YCQAAIKNCQ PRKLHFYKNG IKERFQITRI
81
NKTTARLWY KNFLEPHASM YCTAECPKHF QETLICGKDI
121SSGYPPDIPD EVTCVIYEYS GNMTCTWNAG KLTYIDTKYV
161V
HVKSLETE EEQQYLTSSY INISTDSLQG GKKYLVWVQA
201ANALGMEESK QLQIHLDDIV IPSAAVISRA ETINATVPKT
241II
YWDSQTT IEKVSCEMRY KATTNQTWNV KEFDTNFTYV
281QQSEFYLEPN IKYVFQVRCQ ETGKRYWQPW SSLFFHKTPE
321TVP
QVTSKA FQHDTWNSGL TVASISTGHL TSDNRGDIGL
361LLGMIVFAVM LSILSLIGIF NRSFRTGIKR RILLLIPKWL
401YEDI
PNMKN SNVVKMLQEN SELMNNNSSE QVLYVDPMIT
441EIKEIFIPEH KPTDYKKENT GPLETRDYPQ NSLFDNTTVV
481YIPDL
NTGY KPQISNFLPE GSHLSNNNEI TSLTLKPPVD
521SLDSGNNPRL QKHPNFAFSV SSVNSLSNTI FLGELSLILN
561QGECSS
PDI QNSVEEETTM LLENDSPSET IPEQTLLPDE
601FVSCLGIVNE ELPSINTYFP QNILESHFNR ISLLEK

结构预测来自 AlphaFold DB（UniProt: Q5VWK5），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

IL23R基因的碱基突变：仅显示部分snp

rs736197 rs1158199 rs1321156 rs1884443 rs2064690 rs2064691 rs4655681 rs6588242 rs6588243 rs6666144 rs6693659 rs6703475 rs7543257 rs9724915 rs9729046 rs10789224 rs11582178

IL23R基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CAACATGACTTGCACCTGG

60

GTCTCTAAACTCTTCACATGTACC

59

TGATTCTGAGGCCTTACCAG

59

GTAGAATTCTGACTGTTGCAC

57

AAAGCATTCCAACATGACAC

57

CTCTGTTGTCAGAAGTAAGGT

57

TGAGATGTCAAGAAACAGGC

58

ATAGGACCTGCTCACTGGA

60

TACCAGCCATGTGGAACTG

60

GCTCCAAGTAGAATTCTGACTG

59

AAAGCATTCCAACATGACAC

57

CTCTGTTGTCAGAAGTAAGGT

57

GGATGATATAGTGATACCTTCTGC

59

TAAATTATGGTCTTGGGCACTG

59

GATTCTGAGGCCTTACCAG

57

GTAGAATTCTGACTGTTGCAC

57

AACATGACACATGGAATTCTGG

59

CAATGTCTCCTCTGTTGTCAG

59

AACATGACACATGGAATTCTGG

59

CAATGTCTCCTCTGTTGTCAG

59

尚未收录相关数据

IL23R基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

IL23R基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0001916

Q5VWK5 (UniProtKB)

ISS

GO:0002230

Q5VWK5 (UniProtKB)

ISS

GO:0002230

Q5VWK5 (UniProtKB)

IDA

GO:0002827

Q5VWK5 (UniProtKB)

ISS

GO:0002827

Q5VWK5 (UniProtKB)

IDA

GO:0005515

Q5VWK5 (UniProtKB)

IPI

GO:0005515

Q5VWK5 (UniProtKB)

IPI

GO:0005886

Q5VWK5 (UniProtKB)

TAS

GO:0006954

Q5VWK5 (UniProtKB)

IEA

GO:0010535

Q5VWK5 (UniProtKB)

IC

GO:0032496

Q5VWK5 (UniProtKB)

IDA

GO:0032693

Q5VWK5 (UniProtKB)

IMP

GO:0032725

Q5VWK5 (UniProtKB)

IC

GO:0032729

Q5VWK5 (UniProtKB)

IDA

GO:0032729

Q5VWK5 (UniProtKB)

TAS

GO:0032729

Q5VWK5 (UniProtKB)

IC

GO:0032735

Q5VWK5 (UniProtKB)

IDA

GO:0032740

Q5VWK5 (UniProtKB)

IC

GO:0032819

Q5VWK5 (UniProtKB)

IC

GO:0034341

Q5VWK5 (UniProtKB)

IDA

GO:0038155

Q5VWK5 (UniProtKB)

IEA

GO:0042102

Q5VWK5 (UniProtKB)

IC

GO:0042104

Q5VWK5 (UniProtKB)

IC

GO:0042510

Q5VWK5 (UniProtKB)

IC

GO:0042517

Q5VWK5 (UniProtKB)

IC

GO:0042520

Q5VWK5 (UniProtKB)

IC

GO:0042523

Q5VWK5 (UniProtKB)

IC

GO:0043235

Q5VWK5 (UniProtKB)

IDA

GO:0043382

Q5VWK5 (UniProtKB)

ISS

GO:0045672

Q5VWK5 (UniProtKB)

IC

GO:0050829

Q5VWK5 (UniProtKB)

IC

GO:0051135

Q5VWK5 (UniProtKB)

IC

GO:0072536

Q5VWK5 (UniProtKB)

IDA

GO:2000318

Q5VWK5 (UniProtKB)

ISS

GO:2000330

Q5VWK5 (UniProtKB)

ISS

GO:0005143

Q5VWK5 (UniProtKB)

IPI

GO:0042019

Q5VWK5 (UniProtKB)

IPI

GO:0042020

Q5VWK5 (UniProtKB)

IDA

可能调控 IL23R基因的相关microRNA：

String

BioGrid

IntAct

mentha

加载中…

关联基因	作用方式	资源库来源/分值

KEGG

名称
4630 Jak-STAT signaling pathway [PATH:hsa04630]
4060 Cytokine-cytokine receptor interaction [PATH:hsa04060]
5321 Inflammatiory bowel disease (IBD) [PATH:hsa05321]

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Crohn Disease	0.370597435	101	24	BeFree_CTD_human_GAD_GWASCAT_LHGDN
Inflammatory Bowel Diseases	0.340104897	66	10	BeFree_CTD_human_GAD_GWASCAT_LHGDN
Ulcerative Colitis	0.326936272	59	31	BeFree_CTD_human_GAD_GWASCAT_LHGDN
Psoriasis	0.310524988	45	7	BeFree_CTD_human_GAD_GWASCAT_LHGDN
Ankylosing spondylitis	0.281172083	40	2	BeFree_CTD_human_GAD_GWASCAT_LHGDN
Inflammatory Bowel Disease 17	0.24	1	1	CTD_human_UNIPROT
Behcet Syndrome	0.130358398	12	3	BeFree_GAD_ORPHANET
Uveomeningoencephalitic Syndrome	0.123452799	4	3	BeFree_GAD_GWASCAT
Leprosy	0.120814326	3	0	BeFree_CTD_human
Inflammatory dermatosis	0.12	1	1	GWASCAT

IL-23 serum levels and IL23R polymorphisms in psoriasis: a meta-analysis of susceptibility and severity.

Ahmadipanah S, Shariat Rad P, Montaseri M, Nemati H, Sadeghi M, Ramezani M BMC Immunol IF: 2.485 2026-02-18

Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.

Beecham AH, McGovern DPB, Brugger SW, Davis MF, Torres EA, Gomez L, Li D, Lopez-Marte P, Daly MJ, Stevens C, Yang S, Sinha S, Mengesha E, Leavitt J, Damas OM, Quintero MA, Targan SR, Rabizadeh S, Sabic K, NIDDK IBD Genetics Consortium, Cho JH, Abreu MT, McCauley JL, Haritunians T Gastroenterology IF: 29.7 2026-05-00

Antigenic stimulation in conjunction with cytokine is required for mediating IL-17A production in human MAIT cells.

Kim SJ, Kain D, Lewinsohn DA, Swarbrick GM, Cansler ME, Bimber BN, McElfresh GW, Wong EB, Khuzwayo S, Riffelmacher T, Lewinsohn DM bioRxiv 2026-01-30

Towards a basis for vascular versus intestinal phenotype differences; East Meets West in Behcet's disease.

Abacar K, Macleod T, Alibaz-Oner F, Direskeneli H, McGonagle D Front Immunol IF: 7.0 None

Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.

Tao G, Du H, Zhao J, Zeng Z, Cui J, Lei L Front Immunol IF: 7.0 None

Systematic elucidation of the cross-omics regulatory network in chronic rhinosinusitis: the LAT-IL23R metabolic axis.

Ou Z, Gao C Braz J Otorhinolaryngol IF: 1.8 None

THE1 repeats: Ancient endogenous retroviruses rampaging behind sarcoid myopathy.

Iida A, Funaguma S, Nishino I J Hum Genet IF: 2.3 2026-09-03

In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease.

Altintas Kazar G Genes (Basel) IF: 3.600 2026-06-16

IL12B rs3213094 as a Predictor of Early Response to Biologic Therapy in Psoriasis: A Real-World Study in a Romanian Cohort.

Matei-Man AM, Gaal IO, Catana A, Vesa S, Senila S, Candrea E, Orasan M, Puskas A, Man AC, Mocan T Medicina (Kaunas) IF: 2.9 2026-05-28

Crohn's Disease and Axial Spondyloarthritis: From Systemic Inflammation to Amyloidosis.

Kutsakina DA, Chernichkina AD, Nikolaeva NA, Voronkova OO, Tashchyan OV, Mnatsakanyan MG, Belenkov YN, Osminin SV, Vetshev FP, Bilyalov IR, Panferov AS J Clin Med 2026-05-28

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IL23R (interleukin 23 receptor)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

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