JUN基因详情-基因数据库-基因云馆

JUN (Jun proto-oncogene, AP-1 transcription factor subunit)

symbol:: JUN
locus group:: protein-coding gene
location:: 1p32.1
gene_family:: Basic leucine zipper proteins
alias symbol:: c-Jun|AP-1
alias name:: None
entrez id:: 3725
ensembl gene id:: ENSG00000177606
ucsc gene id:: uc001cze.4
refseq accession:: NM_002228
hgnc_id:: HGNC:6204
approved reserved:: 1988-05-11

1p32.1

JUN基因属于激活蛋白1（AP-1）转录因子家族，该家族还包括FOS、JUNB和JUND等成员。AP-1家族基因的共同特点是编码亮氨酸拉链蛋白，这些蛋白能形成同源或异源二聚体并结合DNA上的特定序列（如TRE或CRE位点），调控下游靶基因的表达，参与细胞增殖、分化、凋亡、炎症反应和应激反应等多种生物学过程。JUN基因编码c-Jun蛋白，是AP-1复合物的核心成分之一，其生物学功能广泛，包括调控细胞周期进程、响应生长因子和细胞外信号（如紫外线或细胞因子刺激）、参与免疫反应以及维持组织稳态。c-Jun在多种组织中表达，尤其在快速增殖的细胞（如上皮细胞和免疫细胞）中活性较高。JUN基因突变或异常表达可导致其功能失调，例如某些突变会削弱其DNA结合能力或二聚化能力，从而影响靶基因的调控。JUN的功能异常与多种疾病相关，包括癌症（如肝癌、乳腺癌和肺癌，其中c-Jun的过表达常促进肿瘤生长和转移）、炎症性疾病（如类风湿性关节炎）和心血管疾病。当JUN过表达时，可能增强细胞增殖并抑制凋亡，促进肿瘤发生，同时可能激活促炎因子（如IL-6和TNF-α）的释放；而降低JUN表达可能导致细胞周期阻滞、凋亡增加或免疫反应减弱。此外，JUN与其他AP-1家族成员（如FOS）的相互作用对功能调控至关重要，例如c-Jun/c-Fos异源二聚体比c-Jun同源二聚体具有更高的转录活性。在发育过程中，JUN的缺失可能影响胚胎器官形成，尤其是肝脏和心脏的发育。总体而言，JUN作为关键的转录调控因子，其表达水平和活性的精细平衡对维持正常生理功能和防止疾病发生至关重要。

中文English

该基因是鸟肉瘤病毒17的推定的转化基因它编码一蛋白，其是高度相似的病毒蛋白，并直接与特定靶DNA序列相互作用，以调节基因表达。这种基因是无内含子并且被映射到1p32-P31，涉及在人类恶性肿瘤都易位和缺失的染色体区域。 [由RefSeq的，2008年7月提供]

OMIM数据库中对JUN基因的介绍 Wikipedia数据库中对JUN基因的介绍

JUN基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL
41NLADPVGSLK PHLRAKNSDL LTSPDVGLLK LASPELERLI
81
IQSSNGHIT TTPTPTQFLC PKNVTDEQEG FAEGFVRALA
121ELHSQNTLPS VTSAAQPVNG AGMVAPAVAS VAGGSGSGGF
161S
ASLHSEPP VYANLSNFNP GALSSGGGAP SYGAAGLAFP
201AQPQQQQQPP HHLPQQMPVQ HPRLQALKEE PQTVPEMPGE
241TP
PLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI
281ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN
321SGC
QLMLTQ QLQTF

结构预测来自 AlphaFold DB（UniProt: P05412），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

JUN基因的碱基突变：仅显示部分snp

rs2654 rs2655 rs9989 rs11688 rs12816 rs1323287 rs1323288 rs1407816 rs1923942 rs2760499 rs2760500 rs2760501 rs2811894 rs3748814 rs3833546 rs4646997 rs4646998

JUN基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

AAGTCATGAACCACGTTAACAG

AAATGTTTGCAACTGCTGC

AGTCATGAACCACGTTAACAG

AAATGTTTGCAACTGCTGC

CAACATGCTCAGGGAACAG

ACTGTTAACGTGGTTCATGAC

转录因子

影响基因

影响类型

参考文献链接（PubMed）

ABL1

JUN

Activation

15145216

ABL1

JUN

Repression

19357699

JUN

Activation

20148354

ARNT

JUN

Repression

21544813

ATF2

JUN

Activation

9502786

CREB1

JUN

Repression

8647095

CREB1

JUN

Unknown

10403485

CTNNB1

JUN

Activation

20300972

CTNNB1

JUN

Unknown

19671687

ESR1

JUN

Activation

11477071

JUN基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

JUN基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000228

P05412 (UniProtKB)

TAS

GO:0000978

P05412 (UniProtKB)

IBA

GO:0000980

P05412 (UniProtKB)

IDA

GO:0000981

P05412 (UniProtKB)

GO:0000982

P05412 (UniProtKB)

IMP

GO:0001077

P05412 (UniProtKB)

IEA

GO:0001102

P05412 (UniProtKB)

IPI

GO:0001190

P05412 (UniProtKB)

GO:0001525

P05412 (UniProtKB)

IEA

GO:0001525

P05412 (UniProtKB)

IEA

GO:0001774

P05412 (UniProtKB)

IEA

GO:0001836

P05412 (UniProtKB)

IEA

GO:0001889

P05412 (UniProtKB)

IEA

GO:0001938

P05412 (UniProtKB)

IEA

GO:0003151

P05412 (UniProtKB)

IEA

GO:0003677

P05412 (UniProtKB)

TAS

GO:0003682

P05412 (UniProtKB)

IEA

GO:0003700

P05412 (UniProtKB)

IDA

GO:0003705

P05412 (UniProtKB)

GO:0003705

P05412 (UniProtKB)

IDA

GO:0003713

P05412 (UniProtKB)

IDA

GO:0005096

P05412 (UniProtKB)

IDA

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005515

P05412 (UniProtKB)

IPI

GO:0005634

P05412 (UniProtKB)

IDA

GO:0005654

P05412 (UniProtKB)

IDA

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005654

P05412 (UniProtKB)

TAS

GO:0005667

P05412 (UniProtKB)

IBA

GO:0005719

P05412 (UniProtKB)

IDA

GO:0005829

P05412 (UniProtKB)

IEA

GO:0006366

P05412 (UniProtKB)

IEA

GO:0007179

P05412 (UniProtKB)

IDA

GO:0007184

P05412 (UniProtKB)

IDA

GO:0007265

P05412 (UniProtKB)

IDA

GO:0007568

P05412 (UniProtKB)

IEA

GO:0007612

P05412 (UniProtKB)

IEA

GO:0007623

P05412 (UniProtKB)

IEA

GO:0008134

P05412 (UniProtKB)

IPI

GO:0008285

P05412 (UniProtKB)

IEA

GO:0009314

P05412 (UniProtKB)

IBA

GO:0009612

P05412 (UniProtKB)

IBA

GO:0010634

P05412 (UniProtKB)

IEA

GO:0010941

P05412 (UniProtKB)

IBA

GO:0017053

P05412 (UniProtKB)

IEA

GO:0019899

P05412 (UniProtKB)

IPI

GO:0030224

P05412 (UniProtKB)

IEA

GO:0031103

P05412 (UniProtKB)

IEA

GO:0031953

P05412 (UniProtKB)

IEA

GO:0032496

P05412 (UniProtKB)

IBA

GO:0032870

P05412 (UniProtKB)

IBA

GO:0034097

P05412 (UniProtKB)

IBA

GO:0035026

P05412 (UniProtKB)

IEA

GO:0035497

P05412 (UniProtKB)

IDA

GO:0035994

P05412 (UniProtKB)

IEA

GO:0038095

P05412 (UniProtKB)

TAS

GO:0042127

P05412 (UniProtKB)

IBA

GO:0042493

P05412 (UniProtKB)

IBA

GO:0042542

P05412 (UniProtKB)

IEA

GO:0042802

P05412 (UniProtKB)

IPI

GO:0042802

P05412 (UniProtKB)

IPI

GO:0042803

P05412 (UniProtKB)

IEA

GO:0043392

P05412 (UniProtKB)

IDA

GO:0043524

P05412 (UniProtKB)

IEA

GO:0043525

P05412 (UniProtKB)

IEA

GO:0043547

P05412 (UniProtKB)

IEA

GO:0043922

P05412 (UniProtKB)

IDA

GO:0043923

P05412 (UniProtKB)

IDA

GO:0044212

P05412 (UniProtKB)

IDA

GO:0044212

P05412 (UniProtKB)

IDA

GO:0044212

P05412 (UniProtKB)

IDA

GO:0044212

P05412 (UniProtKB)

IDA

GO:0044822

P05412 (UniProtKB)

IDA

GO:0045597

P05412 (UniProtKB)

IBA

GO:0045657

P05412 (UniProtKB)

IEA

GO:0045740

P05412 (UniProtKB)

IEA

GO:0045892

P05412 (UniProtKB)

IDA

GO:0045893

P05412 (UniProtKB)

IDA

GO:0045893

P05412 (UniProtKB)

IDA

GO:0045944

P05412 (UniProtKB)

GO:0045944

P05412 (UniProtKB)

IDA

GO:0046982

P05412 (UniProtKB)

IEA

GO:0048146

P05412 (UniProtKB)

IEA

GO:0048661

P05412 (UniProtKB)

IEA

GO:0051090

P05412 (UniProtKB)

TAS

GO:0051365

P05412 (UniProtKB)

IEA

GO:0051591

P05412 (UniProtKB)

IBA

GO:0051726

P05412 (UniProtKB)

IBA

GO:0051899

P05412 (UniProtKB)

IEA

GO:0060395

P05412 (UniProtKB)

IDA

GO:0061029

P05412 (UniProtKB)

IEA

GO:0070374

P05412 (UniProtKB)

IEA

GO:0070412

P05412 (UniProtKB)

IPI

GO:0071277

P05412 (UniProtKB)

IEA

GO:0071837

P05412 (UniProtKB)

IEA

GO:1902895

P05412 (UniProtKB)

ISS

GO:1902895

P05412 (UniProtKB)

IMP

GO:1902895

P05412 (UniProtKB)

IMP

GO:1990441

P05412 (UniProtKB)

IMP

GO:2000144

P05412 (UniProtKB)

IDA

可能调控 JUN基因的相关microRNA：

hsa-miR-101 hsa-miR-26b hsa-miR-29c hsa-mir-30 hsa-miR-30a hsa-let-7b hsa-let-7b* hsa-let-7e* hsa-miR-100 hsa-miR-100*

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4310 Wnt signaling pathway [PATH:hsa04310]
4668 TNF signaling pathway [PATH:hsa04668]
4024 cAMP signaling pathway [PATH:hsa04024]
4510 Focal adhesion [PATH:hsa04510]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4912 GnRH signaling pathway [PATH:hsa04912]
4915 Estrogen signaling pathway [PATH:hsa04915]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4380 Osteoclast differentiation [PATH:hsa04380]
5200 Pathways in cancer [PATH:hsa05200]
5231 Choline metabolism in cancer [PATH:hsa05231]
5203 Viral carcinogenesis [PATH:hsa05203]
5210 Colorectal cancer [PATH:hsa05210]
5211 Renal cell carcinoma [PATH:hsa05211]
5323 Rheumatoid arthritis [PATH:hsa05323]
5321 Inflammatiory bowel disease (IBD) [PATH:hsa05321]
5030 Cocaine addiction [PATH:hsa05030]
5031 Amphetamine addiction [PATH:hsa05031]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
5132 Salmonella infection [PATH:hsa05132]
5133 Pertussis [PATH:hsa05133]
5166 HTLV-I infection [PATH:hsa05166]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5168 Herpes simplex infection [PATH:hsa05168]
5169 Epstein-Barr virus infection [PATH:hsa05169]
5140 Leishmaniasis [PATH:hsa05140]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

名称
Activated TLR4 signalling
Activation of the AP-1 family of transcription factors
Cellular responses to stress
Cellular Senescence
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
Immune System
Innate Immune System
MAP kinase activation in TLR cascade
MAPK targets/ Nuclear events mediated by MAP kinases
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88-independent TLR3/TLR4 cascade
MyD88:Mal cascade initiated on plasma membrane
Oxidative Stress Induced Senescence
Pre-NOTCH Expression and Processing
Pre-NOTCH Transcription and Translation
Senescence-Associated Secretory Phenotype (SASP)
Signal Transduction
Signaling by NOTCH
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor 9 (TLR9) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll-Like Receptors Cascades
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 Mediated Induction of proinflammatory cytokines
TRIF-mediated TLR3/TLR4 signaling

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Mammary Neoplasms	0.134164635	8	0	BeFree_CTD_human_LHGDN
Liver carcinoma	0.128434561	13	0	BeFree_CTD_human_LHGDN
Osteosarcoma	0.125720142	4	0	BeFree_CTD_human_LHGDN
Stomach Neoplasms	0.1254487	3	0	CTD_human_LHGDN
Colonic Neoplasms	0.12272435	3	0	CTD_human_LHGDN
Lung Neoplasms	0.12272435	2	0	CTD_human_LHGDN
Liver neoplasms	0.121085767	6	0	BeFree_CTD_human
Mercury Poisoning, Nervous System	0.12	1	0	CTD_human
Intestinal Polyps	0.12	1	0	CTD_human
Reperfusion Injury	0.12	1	0	CTD_human

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JUN (Jun proto-oncogene, AP-1 transcription factor subunit)

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