LAMTOR1基因详情-基因数据库-基因云馆

LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)

symbol:: LAMTOR1
locus group:: protein-coding gene
location:: 11q13.4
gene_family:
alias symbol:: FLJ20625|p18|p27RF-Rho|Pdro|Ragulator1
alias name:: p27kip1 releasing factor from Rh...
entrez id:: 55004
ensembl gene id:: ENSG00000149357
ucsc gene id:: uc001ort.3
refseq accession:: NM_017907
hgnc_id:: HGNC:26068
approved reserved:: 2006-03-09

11q13.4

LAMTOR1（也称为Ragulator1或p18）是溶酶体适配器和代谢调节因子复合物（LAMTOR/Ragulator）的关键组成部分，属于LAMTOR基因家族。该家族包括LAMTOR1-5，共同形成Ragulator复合物，作为溶酶体膜上的支架蛋白，参与调控mTORC1信号通路（哺乳动物雷帕霉素靶蛋白复合物1），这一通路对细胞生长、代谢和自噬至关重要。LAMTOR1作为复合物的核心亚基，负责将Rag GTPases（RagA/B和RagC/D）锚定到溶酶体膜上，从而在氨基酸感应条件下激活mTORC1。其生物学功能主要体现在营养信号传递、细胞代谢平衡及自噬调控中。LAMTOR1的表达或功能异常可能直接干扰mTORC1的定位与活性，导致代谢紊乱。例如，突变或缺失可能引发mTORC1信号缺陷，表现为细胞生长停滞、自噬过度激活或发育异常；而过表达则可能过度激活mTORC1，与肿瘤发生相关（如肾癌、肝癌），因其促进细胞增殖并抑制自噬。此外，LAMTOR1在免疫细胞中调控炎症反应，其缺失会损害巨噬细胞和T细胞功能。LAMTOR家族成员的共性是均定位于溶酶体，通过相互作用维持复合物稳定性，并协同传递上游信号至mTORC1。若LAMTOR1表达降低，可能削弱溶酶体对氨基酸的敏感性，影响蛋白质合成和能量代谢；而过表达可能破坏信号平衡，诱发病理状态。研究还发现LAMTOR1与神经退行性疾病（如阿尔茨海默病）相关，可能通过自噬障碍导致毒性蛋白积累。总之，LAMTOR1是代谢与疾病关联的重要节点基因，其功能调控具有广泛生理及病理意义。

中文English

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OMIM数据库中对LAMTOR1基因的介绍 Wikipedia数据库中对LAMTOR1基因的介绍

LAMTOR1基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY
41HSLPSARTDE QALLSSILAK TASNIIDVSA ADSQGMEQHE
81
YMDRARQYS TRLAVLSSSL THWKKLPPLP SLTSQPHQVL
121ASEPIPFSDL QQVSRIAAYA YSALSQIRVD AKEELVVQFG
161I
P

结构预测来自 AlphaFold DB（UniProt: Q6IAA8），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

LAMTOR1基因的碱基突变：仅显示部分snp

rs12137 rs510925 rs542752 rs595062 rs659513 rs1053443 rs1053573 rs2508856 rs3750911 rs4365081 rs4943821 rs5792575 rs10898820 rs12272086 rs12272213 rs12293885 rs12807065

LAMTOR1基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CTGATTTGCAGCAGGTCTC

59

AACTGTACAACCAGCTCCTC

60

CAAAGCTCTCAATGGAGCC

59

TCAATGATGTTGCTGGCTG

59

CAAAGCTCTCAATGGAGCC

59

TCAATGATGTTGCTGGCTG

59

CATTGGAAGAAGCTGCCAC

60

CTGAAACAGCTGAACCTGC

60

CAAAGCTCTCAATGGAGCC

58

TCAATGATGTTGCTGGCTG

58

TCATTGATGTGTCTGCTGC

59

ATCCTGGAGACCTGTACTG

58

ATCATTGATGTGTCTGCTGC

59

CCTGTATGTCTGTACTGCCT

59

CAAAGCTCTCAATGGAGCC

59

TCAATGATGTTGCTGGCTG

59

CTGATTTGCAGCAGGTCTC

59

AACTGTACAACCAGCTCCTC

60

CCAAAGCTCTCAATGGAGC

59

AATGATGTTGCTGGCTGTC

59

尚未收录相关数据

LAMTOR1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

LAMTOR1基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0001919

F5GX19 (UniProtKB)

IEA

GO:0005794

F5GX19 (UniProtKB)

IDA

GO:0005886

F5GX19 (UniProtKB)

IDA

GO:0007040

F5GX19 (UniProtKB)

IEA

GO:0032008

F5GX19 (UniProtKB)

IEA

GO:0032439

F5GX19 (UniProtKB)

IEA

GO:0042632

F5GX19 (UniProtKB)

IEA

GO:0043231

F5GX19 (UniProtKB)

IDA

GO:0043410

F5GX19 (UniProtKB)

IEA

GO:0071230

F5GX19 (UniProtKB)

IEA

GO:0071986

F5GX19 (UniProtKB)

IEA

GO:0001919

F5H3Y3 (UniProtKB)

IEA

GO:0005794

F5H3Y3 (UniProtKB)

IDA

GO:0005886

F5H3Y3 (UniProtKB)

IDA

GO:0007040

F5H3Y3 (UniProtKB)

IEA

GO:0032008

F5H3Y3 (UniProtKB)

IEA

GO:0032439

F5H3Y3 (UniProtKB)

IEA

GO:0042632

F5H3Y3 (UniProtKB)

IEA

GO:0043231

F5H3Y3 (UniProtKB)

IDA

GO:0043410

F5H3Y3 (UniProtKB)

IEA

GO:0071230

F5H3Y3 (UniProtKB)

IEA

GO:0071986

F5H3Y3 (UniProtKB)

IEA

GO:0001919

F5H479 (UniProtKB)

IEA

GO:0007040

F5H479 (UniProtKB)

IEA

GO:0032008

F5H479 (UniProtKB)

IEA

GO:0032439

F5H479 (UniProtKB)

IEA

GO:0042632

F5H479 (UniProtKB)

IEA

GO:0043410

F5H479 (UniProtKB)

IEA

GO:0071230

F5H479 (UniProtKB)

IEA

GO:0071986

F5H479 (UniProtKB)

IEA

GO:0001919

H0YFI1 (UniProtKB)

IEA

GO:0007040

H0YFI1 (UniProtKB)

IEA

GO:0032008

H0YFI1 (UniProtKB)

IEA

GO:0032439

H0YFI1 (UniProtKB)

IEA

GO:0042632

H0YFI1 (UniProtKB)

IEA

GO:0043410

H0YFI1 (UniProtKB)

IEA

GO:0071230

H0YFI1 (UniProtKB)

IEA

GO:0071986

H0YFI1 (UniProtKB)

IEA

GO:0001919

Q6IAA8 (UniProtKB)

ISS

GO:0005515

Q6IAA8 (UniProtKB)

IPI

GO:0005515

Q6IAA8 (UniProtKB)

IPI

GO:0005515

Q6IAA8 (UniProtKB)

IPI

GO:0005515

Q6IAA8 (UniProtKB)

IPI

GO:0005515

Q6IAA8 (UniProtKB)

IPI

GO:0005764

Q6IAA8 (UniProtKB)

IDA

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005765

Q6IAA8 (UniProtKB)

TAS

GO:0005794

Q6IAA8 (UniProtKB)

IDA

GO:0005886

Q6IAA8 (UniProtKB)

IDA

GO:0007032

Q6IAA8 (UniProtKB)

ISS

GO:0007040

Q6IAA8 (UniProtKB)

ISS

GO:0007050

Q6IAA8 (UniProtKB)

TAS

GO:0010872

Q6IAA8 (UniProtKB)

IMP

GO:0010874

Q6IAA8 (UniProtKB)

IMP

GO:0016049

Q6IAA8 (UniProtKB)

IMP

GO:0016236

Q6IAA8 (UniProtKB)

TAS

GO:0031902

Q6IAA8 (UniProtKB)

ISS

GO:0032008

Q6IAA8 (UniProtKB)

IMP

GO:0032418

Q6IAA8 (UniProtKB)

ISS

GO:0032439

Q6IAA8 (UniProtKB)

ISS

GO:0034613

Q6IAA8 (UniProtKB)

IMP

GO:0042632

Q6IAA8 (UniProtKB)

IMP

GO:0043231

Q6IAA8 (UniProtKB)

IDA

GO:0043410

Q6IAA8 (UniProtKB)

ISS

GO:0043547

Q6IAA8 (UniProtKB)

IEA

GO:0045121

Q6IAA8 (UniProtKB)

ISS

GO:0060620

Q6IAA8 (UniProtKB)

IMP

GO:0070062

Q6IAA8 (UniProtKB)

IDA

GO:0070062

Q6IAA8 (UniProtKB)

IDA

GO:0071230

Q6IAA8 (UniProtKB)

IMP

GO:0071986

Q6IAA8 (UniProtKB)

IDA

GO:0005085

Q6IAA8 (UniProtKB)

IDA

GO:0032947

Q6IAA8 (UniProtKB)

IDA

可能调控 LAMTOR1基因的相关microRNA：

hsa-let-7c hsa-miR-16 hsa-miR-20a

String

BioGrid

IntAct

mentha

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关联基因	作用方式	资源库来源/分值

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
leukemia	0.001357209	5	0	BeFree
Carcinogenesis	0.001085767	4	0	BeFree
Acute leukemia	0.000814326	3	0	BeFree
Liver carcinoma	0.000542884	2	0	BeFree
Retinopathy of Prematurity	0.000542884	2	0	BeFree
Parathyroid Adenoma	0.000542884	2	0	BeFree
Meningioma	0.000542884	2	0	BeFree
Hemorrhagic Fevers, Viral	0.000542884	2	0	BeFree
melanoma	0.000542884	2	0	BeFree
Multiple Myeloma	0.000542884	2	0	BeFree

Cholesterol-dependent lysosomal docking of mTORC1 mediated by TM6SF1.

Hong S, Jia L, Wang R, Elghobashi-Meinhardt N, Hobbs HH, Li X bioRxiv 2026-04-03

ZDHHC9 palmitoylates LAMTOR1 to promote renal cell carcinoma malignant progression.

Liu B, Hou T, Liu X, Liu L, Ma Z, Zhang Y Cell Death Dis IF: 12.2 2026-03-19

LAMTOR1 sorts APP to late endosomes via AP-3-mediated trafficking.

Zhou C, Cao W, Cong R, Shan C, Tian Y, Xu S, Feng W, Li Y, Wang X, Teng J, Zheng P, Huang N, Chen J J Mol Cell Biol IF: 6.0 2026-08-26

The SLC15A4-LAMTOR1 interaction licenses endolysosomal TLR-mediated mTOR signaling and inflammatory cytokine production.

Chiu TY, Hall PR, Lazar DC, Kim AS, Forli S, Ward AB, Teijaro JR, Parker CG bioRxiv 2026-06-09

Inhibition of lysosomal LAMTOR1 increases autophagy by suppressing the MTORC1 pathway to ameliorate lipid accumulations in MAFLD.

Jang Y, Ko M, Lee JY, Kim JY, Lee EW, Kwon HJ Autophagy IF: 18.6 2025-12-00

Regulation of Tetraspanin CD63 in Chronic Myeloid Leukemia (CML): Single-Cell Analysis of Asymmetric Hematopoietic Stem Cell Division Genes.

Desterke C, Bennaceur-Griscelli A, Turhan AG Bioengineering (Basel) 2025-07-31

Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation.

Zada Sahib, Noh Hae Sook, Baek Seon Mi, Ha Ji Hye, Hahm Jong Ryeal, Kim Deok Ryong Cell Biol Int IF: 3.5 2016-08-17

LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13).

Panagopoulos Ioannis, Gorunova Ludmila, Bjerkehagen Bodil, Lobmaier Ingvild, Heim Sverre Cancer Genet IF: 11.0 2016-03-04

Identification of prostate cancer biomarkers in urinary exosomes.

Øverbye Anders, Skotland Tore, Koehler Christian J, Thiede Bernd, Seierstad Therese, Berge Viktor, Sandvig Kirsten, Llorente Alicia Oncotarget IF: 5.168 2016-08-02

Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.

Płaszczyca Anna, Nilsson Jenny, Magnusson Linda, Brosjö Otte, Larsson Olle, Vult von Steyern Fredrik, Domanski Henryk A, Lilljebjörn Henrik, Fioretos Thoas, Tayebwa Johnbosco, Mandahl Nils, Nord Karolin H, Mertens Fredrik Int J Biochem Cell Biol IF: 3.5 2015-03-31

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LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

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基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

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