LNCTAM34A (long non coding transcriptional activator of miR34a)

Gene Basic Information

Gene Basic Information

symbol:
LNCTAM34A
locus group:
non-coding RNA
location:
1p36.22
gene_family:
None
alias symbol:
GUARDIN|TP53LC18
alias name:
None
entrez id:
102724571
ensembl gene id:
ENSG00000234546
ucsc gene id:
None
refseq accession:
NR_132738
hgnc_id:
HGNC:52548
approved reserved:
2016-11-08

Chromosome Location

Chromosome Location

1p36.22

Gene Summary

Gene Summary

LNCTAM34A（长链非编码RNA TAM34A）是一种长链非编码RNA（lncRNA），属于lncRNA基因家族。lncRNA家族是一类长度超过200个核苷酸的非编码RNA分子，虽然不编码蛋白质，但通过调控基因表达、染色质修饰、信号传导等机制在多种生物学过程中发挥重要作用。LNCTAM34A的具体功能尚未完全阐明，但研究表明它可能参与细胞增殖、分化和免疫调节等过程。其作用位点可能涉及与特定蛋白质或RNA分子相互作用，从而影响下游信号通路或基因表达网络。突变或异常表达可能导致其调控功能失调，进而影响相关生理过程，甚至与某些疾病如癌症、自身免疫性疾病或神经退行性疾病的发生发展相关。过表达LNCTAM34A可能促进细胞增殖或抑制凋亡，而降低表达则可能导致细胞周期阻滞或功能异常。此外，LNCTAM34A可能与其他基因或通路（如Wnt/β-catenin或NF-κB）存在交叉调控，从而放大或抑制其生物学效应。lncRNA家族的共性包括高度组织特异性表达、复杂的调控机制以及在发育和疾病中的关键作用。尽管LNCTAM34A的具体机制仍需进一步研究，但其作为lncRNA的潜在功能使其成为疾病诊断或治疗的潜在靶点。

OMIM entry for LNCTAM34A     Wikipedia entry for LNCTAM34A

Gene Sequence

Gene Sequence

Nucleotide sequence of LNCTAM34A:[NCBI]
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Gene Variants

Gene Variants

SNP variants of LNCTAM34A:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of LNCTAM34A:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of LNCTAM34A (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for LNCTAM34A:

Related microRNA

Related microRNA

microRNAs potentially regulating LNCTAM34A:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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