LRRFIP1 (LRR binding FLII interacting protein 1)

基因基本信息

基因基本信息

symbol:
LRRFIP1
locus group:
protein-coding gene
location:
2q37.3
gene_family:
alias symbol:
FLAP-1|FLIIAP1|TRIP|GCF-2|HUFI-1|GCF2
alias name:
GC-binding factor 2
entrez id:
9208
ensembl gene id:
ENSG00000124831
ucsc gene id:
uc002vxd.4
refseq accession:
NM_004735
hgnc_id:
HGNC:6702
approved reserved:
1999-02-15

基因染色体位置

基因染色体位置

2q37.3

基因简述

基因简述

LRRFIP1（Leucine Rich Repeat Flightless Interacting Protein 1）是一种富含亮氨酸重复序列的蛋白质编码基因，属于LRRFIP基因家族。该家族成员通常含有亮氨酸重复序列（LRR）和Flightless-1相互作用结构域，这些结构域在蛋白质相互作用和信号转导中起重要作用。LRRFIP1主要参与调控先天免疫反应、细胞骨架重组和转录调控等生物学过程。它在巨噬细胞和树突状细胞中高表达，通过与Toll样受体（TLR）信号通路中的关键分子相互作用，调节炎症因子的产生。LRRFIP1还能结合细胞骨架蛋白Flightless-1，影响细胞迁移和形态变化。突变或表达异常可能导致免疫失调，与自身免疫性疾病如系统性红斑狼疮（SLE）和类风湿性关节炎（RA）有关。研究表明，LRRFIP1过表达可能增强TLR信号通路的激活，导致过度炎症反应；而降低表达则可能削弱免疫防御功能，增加感染风险。此外，LRRFIP1还参与Wnt/β-catenin信号通路的调控，影响细胞增殖和分化，其异常表达可能与某些癌症的发展相关。LRRFIP基因家族的共性包括参与免疫调节、细胞信号转导和细胞骨架动力学，成员间在结构和功能上具有相似性。LRRFIP1的具体作用机制仍在研究中，但其在免疫和炎症反应中的关键作用已得到广泛认可。

中文English

无

OMIM数据库中对LRRFIP1基因的介绍     Wikipedia数据库中对LRRFIP1基因的介绍

基因序列

基因序列

LRRFIP1基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI
41RMKELERQQK EEDSERYSRR SRRNTSASDE DERMSVGSRG
81 SLRVEERPE KDFTEKGSRN MPGLSAATLA SLGGTSSRRG
121SGDTSISIDT EASIREIKEL NELKDQIQDV EGKYMQGLKE
161M KDSLAEVE EKYKKAMVSN AQLDNEKTNF MYQVDTLKDM
201LLELEEQLAE SRRQYEEKNK EFEREKHAHS ILQFQFAEVK
241EA LKQREEM LEKHGIILNS EIATNGETSD TLNNVGYQGP
281TKMTKEELNA LKSTGDGTLG RASEVEVKNE IVANVGKREI
321LHN TEKEQH TEDTVKDCVD IEVFPAGENT EDQKSSEDTA
361PFLGTLAGAT YEEQVQSQIL ESSSLPENTV QVESNEVMGA
401PDDR TRTPL EPSNCWSDLD GGNHTENVGE AAVTQVEEQA
441GTVASCPLGH SDDTVYHDDK CMVEVPQELE TSTGHSLEKE
481FTNQE AAEP KEVPAHSTEV GRDHNEEEGE ETGLRDEKPI
521KTEVPGSPAG TEGNCQEATG PSTVDTQNEP LDMKEPDEEK
561SDQQGE ALD SSQKKTKNKK KKNKKKKSPV PVETLKDVKK
601ELTYQNTDLS EIKEEEQVKS TDRKSAVEAQ NEVTENPKQK
641IAAESSE NV DCPENPKIKL DGKLDQEGDD VQTAAEEVLA
681DGDTLDFEDD TVQSSGPRAG GEELDEGVAK DNAKIDGATQ
721SSPAEPKS E DADRCTLPEH ESPSQDISDA CEAESTERCE
761MSEHPSQTVR KALDSNSLEN DDLSAPGREP GHFNPESRED
801TRGGNEKGK SKEDCTMS
结构预测来自 AlphaFold DB（UniProt: Q32MZ4），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

LRRFIP1基因的碱基突变：           仅显示部分snp
rs1565854       rs1565855       rs3754727       rs3754728       rs3769107       rs4142730       rs4459685       rs4459686       rs4663265       rs4663782       rs4663783       rs5839674       rs6431556       rs6431557       rs6710238       rs6739947       rs6743986      

基因表达

基因表达

LRRFIP1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGAAACACATCGGCTTCTG
58
GCCTTCATCCAACACAGAC
58
GGCAAACTAGACAATCTTCGA
58
CATCCCATGCATGTCTGTC
58
ATGGACCTACAAAGGGATGC
59
AATGCAGTTATCTCTTGCTCAG
58
AGAAACACATCGGCTTCTG
58
ATCATTCTGGTTACTGACCCT
58
CTTCAAAGTGGCTCACACC
59
GGTCTTGAATTCCTGGCCT
59
GAGATCGACTGTTTGAGCC
58
CTTCATCAGAAGCCGATGTG
59
AGAAACACATCGGCTTCTG
58
CCATACTCCAAGTCAGGCT
58
CCACAGTATACTGCAATTTCAG
57
ATTCCATGTTTCTCGAGCA
57
TCTGAGCAAGAGATAACTGC
57
TGTAACGTGATACTTGACTCTC
57
ATCAGGGAAATCAAGGACTCTC
59
ATTGTCTAGCTGAGCATTGGA
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
LRRFIP1
EGFR
Repression
14522076
LRRFIP1
TNF
Repression
16199883

基因本体信息

LRRFIP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LRRFIP1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006355
C9JTC6 (UniProtKB)
IEA
GO:0003677
Q32MZ4 (UniProtKB)
IDA
GO:0003725
Q32MZ4 (UniProtKB)
TAS
GO:0005515
Q32MZ4 (UniProtKB)
IPI
GO:0005515
Q32MZ4 (UniProtKB)
IPI
GO:0005515
Q32MZ4 (UniProtKB)
IPI
GO:0005515
Q32MZ4 (UniProtKB)
IPI
GO:0005575
Q32MZ4 (UniProtKB)
ND
GO:0005634
Q32MZ4 (UniProtKB)
NAS
GO:0005737
Q32MZ4 (UniProtKB)
IDA
GO:0005829
Q32MZ4 (UniProtKB)
TAS
GO:0005829
Q32MZ4 (UniProtKB)
TAS
GO:0005829
Q32MZ4 (UniProtKB)
TAS
GO:0005856
Q32MZ4 (UniProtKB)
TAS
GO:0005886
Q32MZ4 (UniProtKB)
IDA
GO:0006351
Q32MZ4 (UniProtKB)
IEA
GO:0006357
Q32MZ4 (UniProtKB)
TAS
GO:0008150
Q32MZ4 (UniProtKB)
ND
GO:0032481
Q32MZ4 (UniProtKB)
TAS
GO:0042803
Q32MZ4 (UniProtKB)
IDA
GO:0045892
Q32MZ4 (UniProtKB)
NAS

基因相关microRNA

基因相关microRNA

可能调控 LRRFIP1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
Reactome
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关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Tobacco Use Disorder 0.002367032 1 0 GAD
Glioblastoma 0.000542884 2 0 BeFree
Glioblastoma Multiforme 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Pneumocystis jiroveci pneumonia 0.000271442 1 0 BeFree
Cerebrovascular accident 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

Epithelioid Fibrous Histiocytoma with LRRFIP1::ALK Fusion and Smooth Muscle Hyperplasia.
Davenne E, Fortun A, Matthews M, Secco LP Int J Surg Pathol IF: 0.9 2026-05-06
Identification of potential diagnostic and therapeutic apoptosis-related casual targets for osteoporosis: an integrated multi-omics analysis.
Wang Y, Xia L, Xiao Y, Wu M, Zhang R, Rexiti P, Zhang H J Bone Miner Metab IF: 2.9 2026-07-00
Aging Reprograms the Signaling, Metabolic, and Gene Regulatory Dynamics in Murine Bone Marrow-Derived Mesenchymal Stem Cells.
Hossain Tanim MT, Patel A, Pandit V, Fracek L, Nohe A Appl Sci (Basel) IF: 1.679 2026-04-02
Catch me if you can: viral nucleic acids to host sensors.
Jung Y, Grainger H, Yang S, Mondal S, Lukong KE, Conn K, Wu Y Front Immunol IF: 7.0 2025-00-00
SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.
Wei Ning, Cheng Yuanming, Wang Zhijia, Liu Yuguo, Luo Chunling, Liu Lina, Chen Linlin, Xie Zhiqin, Lu Yun, Feng Ying Cell Rep IF: 6.9 2016-09-07
Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway.
Douchi Daisuke, Ohtsuka Hideo, Ariake Kyohei, Masuda Kunihiro, Kawasaki Shuhei, Kawaguchi Kei, Fukase Koji, Oikawa Masaya, Motoi Fuyuhiko, Naitoh Takeshi, Katayose Yu, Egawa Shinichi, Unno Michiaki Cancer Lett IF: 11.8 2015-08-24
LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes.
Liu Yuan, Zou Ziying, Zhu Bing, Hu Zonghai, Zeng Ping, Wu Lijuan Hepat Mon IF: 0.5 2015-06-05
Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.
Rotival Maxime, Ko Jeong-Hun, Srivastava Prashant K, Kerloc'h Audrey, Montoya Alex, Mauro Claudio, Faull Peter, Cutillas Pedro R, Petretto Enrico, Behmoaras Jacques Mol Cell Proteomics IF: 6.540 2015-12-03
[Whole genome methylation profiles of myelodysplastic syndrome and its diagnostic value].
Zhao Xiaoli, Wang Xiaoqin, Li Shuang, Li Nianyi, Ma Yan, Lin Guowei Zhonghua Xue Ye Xue Za Zhi 2015-05-16

基因相关服务

基因相关服务

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