LCN2 (lipocalin 2)

Gene Basic Information

Gene Basic Information

symbol
LCN2
locus group
protein-coding gene
location
9q34.11
gene_family
Lipocalins
alias symbol
NGAL|24p3
alias name
oncogene 24p3|neutrophil gelatinas…
entrez id
3934
ensembl gene id
ENSG00000148346
ucsc gene id
uc064wbc.1
refseq accession
NM_005564
hgnc_id
HGNC:6526
approved reserved
1994-04-29

Chromosome Location

Chromosome Location

9q34.11

Gene Summary

Gene Summary

脂质运载蛋白2（LCN2），也称为中性粒细胞明胶酶相关脂质运载蛋白（NGAL），是一种由LCN2基因编码的分泌型蛋白质，属于脂质运载蛋白家族。该家族成员通常具有保守的β-桶状结构，能够结合和运输疏水性分子如脂质、类固醇和铁载体等。LCN2在先天免疫、炎症反应和铁代谢中发挥重要作用，尤其在细菌感染时通过螯合铁载体限制细菌生长。其主要作用位点包括肾脏、肝脏、脂肪组织和免疫细胞。LCN2突变可能导致其功能丧失，影响机体对感染的防御能力或铁代谢平衡，与多种疾病相关，如急性肾损伤（AKI）、慢性肾病（CKD）、肥胖相关代谢紊乱、某些癌症和炎症性疾病。LCN2过表达常见于炎症和损伤状态，可能加剧组织损伤或促进肿瘤进展，而降低表达可能削弱抗菌防御或影响铁稳态。在肾脏中，LCN2过表达是肾小管损伤的早期标志物，而在脂肪组织中，它与胰岛素抵抗和代谢综合征相关。脂质运载蛋白家族成员共享结合和转运小分子配体的能力，并参与多种生理和病理过程。LCN2作为该家族的重要成员，其表达水平变化可影响其他基因或通路，如通过调节铁代谢影响炎症反应或通过参与细胞凋亡和增殖影响组织修复。

OMIM entry for LCN2     Wikipedia entry for LCN2

Gene Sequence

Gene Sequence

Nucleotide sequence of LCN2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MPLGLLWLGL ALLGALHAQA QDSTSDLIPA PPLSKVPLQQ
41NFQDNQFQGK WYVVGLAGNA ILREDKDPQK MYATIYELKE
81 DKSYNVTSV LFRKKKCDYW IRTFVPGCQP GEFTLGNIKS
121YPGLTSYLVR VVSTNYNQHA MVFFKKVSQN REYFKITLYG
161R TKELTSEL KENFIRFSKS LGLPENHIVF PVPIDQCIDG
Structure predicted by AlphaFold DB(UniProt: P80188). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of LCN2:           Showing partial SNPs
rs11927       rs12260       rs1061879       rs2232623       rs2232624       rs2232625       rs2232626       rs2232627       rs2232628       rs2232629       rs2232630       rs2232631       rs2232632       rs3780836       rs3780837       rs3814526       rs3837300      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CCATCTATGAGCTGAAAGAAGAC
59
CCAGTAGTCACACTTCTGGG
60
GTGTGACTACTGGATCAGGA
59
CCAGGGTAACTCTTAATGTTGC
59
GTGTGACTACTGGATCAGGA
58
CCAGGGTAACTCTTAATGTTGC
59
TTCCAGGACAACCAATTCC
58
CGGGTCTTTGTCTTCTCTG
58
TTCCAGGACAACCAATTCC
58
CGGGTCTTTGTCTTCTCTG
58
AGAACTTCATCCGCTTCTC
57
CGATACACTGGTCGATTGG
58
TCCAGGACAACCAAGTGAG
59
GAGGTGAACGACAGGATCC
60
TCCAGGACAACCAAGTGAG
59
GAGGTGAACGACAGGATCC
60
CACCTCCGTCCTGTTTAGG
60
CCAGGGTAACTCTTAATGTTGC
59
CTATGAGCTGAAAGAAGACAAGAG
59
ATCCAGTAGTCACACTTCTGG
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
NFKB1
LCN2
Activation
15536164
NFKB1
LCN2
Unknown
19707556; 20220144; 24391115
NR3C2
LCN2
Unknown
22469622
RELA
LCN2
Activation
15536164
RELA
LCN2
Unknown
19707556; 20220144; 24391115
STAT1
LCN2
Unknown
24391115

Gene Ontology

Subcellular localization of LCN2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for LCN2:

GO ID
Protein
Source DB
GO:0005215
P80188 (UniProtKB)
IEA
GO:0005506
P80188 (UniProtKB)
ISS
GO:0005576
P80188 (UniProtKB)
ISS
GO:0005576
P80188 (UniProtKB)
TAS
GO:0005576
P80188 (UniProtKB)
TAS
GO:0005615
P80188 (UniProtKB)
IDA
GO:0005615
P80188 (UniProtKB)
IDA
GO:0005615
P80188 (UniProtKB)
IDA
GO:0005623
P80188 (UniProtKB)
IEA
GO:0005623
P80188 (UniProtKB)
IEA
GO:0006811
P80188 (UniProtKB)
IEA
GO:0006879
P80188 (UniProtKB)
TAS
GO:0006915
P80188 (UniProtKB)
IEA
GO:0015891
P80188 (UniProtKB)
ISS
GO:0036094
P80188 (UniProtKB)
IEA
GO:0045087
P80188 (UniProtKB)
ISS
GO:0070062
P80188 (UniProtKB)
IDA
GO:0070062
P80188 (UniProtKB)
IDA
GO:0070062
P80188 (UniProtKB)
IDA
GO:0005215
X6R8F3 (UniProtKB)
IEA
GO:0005576
X6R8F3 (UniProtKB)
IEA
GO:0006810
X6R8F3 (UniProtKB)
IEA
GO:0036094
X6R8F3 (UniProtKB)
IEA

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Acute kidney injury 0.2 4 0 CTD_human_RGD
Neoplasm Metastasis 0.127338862 19 0 BeFree_CTD_human_LHGDN
Kidney Diseases 0.126534468 9 0 BeFree_CTD_human_LHGDN
beta Thalassemia 0.122995792 2 0 BeFree_CTD_human_LHGDN
Inflammation 0.12272435 2 0 CTD_human_LHGDN
Chronic Kidney Insufficiency 0.120542884 3 0 BeFree_CTD_human
Drug-Induced Liver Injury 0.12 2 0 CTD_human
Rheumatoid Arthritis 0.12 1 0 CTD_human
Contact Dermatitis 0.12 1 0 CTD_human
Calcinosis 0.12 1 0 CTD_human

Related Publications

Related Publications

Shared Biomarkers LCN2 and CXCL11 for Ulcerative Colitis and Colon Cancer: Bioinformatics Analysis and Diagnostic Model Construction.
Wu Z, Sun X, Li B, Xie Z, Zheng J, Sun N, Guan Y, Chen J Dig Dis Sci IF: 2.8 2026-03-00
Identification of specific molecular markers in severe heatstroke using transcriptomics techniques.
Duan Z, Wang M, Zhou Y, Lu J, Ma Y, Xu Y, Deng J, Liu H, Chen J Int J Legal Med IF: 2.6 2026-01-00
Synovial fluid Lipocalin-2 as a biomarker for chronic prosthetic joint infection: Prospective validation in hip and knee revision arthroplasty.
Alías A, Fernández-Valencia JA, Martínez-Pastor JC, Sabater-Martos M, Tornero E, Vergara A, Combalia A, Morata L, Soriano A, Muñoz-Mahamud E Rev Esp Cir Ortop Traumatol 2026-00-00
Brazilin attenuates kidney ischemia-reperfusion injury by regulating inflammation, oxidative stress, and mitochondrial dysfunction.
Zhao J, Zhang L, Mu F, Yu Y, Cui C, Tang M, Sun K, Yin Y, Wang J, Gong R Histol Histopathol IF: 2.2 2026-04-00
LCN2-ACOD1 Signalling Affects the Post-Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis.
Hao X, Shi H, Wu D, Liang R, Zhao T, Sun W, Wang Y, Yu X, Luo X, Yan Y, Lu J, Wang H, Wang J Cell Prolif IF: 7.6 2026-04-00
Human Liver Organoids as an Experimental Tool to Investigate Lipocalin-2 in Hepatic Inflammation.
Hardt KS, Pohlberger RF, Keller DT, Buhl EM, Vondran FWR, Roeth AA, Weiskirchen R, Schröder-Lange SK Cells 2026-01-23
Neutrophil Gelatinase-Associated Lipocalin Drives Cardiac Remodeling in Rats With Chronic Kidney Disease.
Soulié M, Sánchez-Bayuela T, Lima-Posada I, Stephan Y, Nicol L, Lamiral Z, Lagrange J, Voors A, Lopez-Andres N, Girerd N, Mulder P, Jaisser F Hypertension IF: 9.8 2026-06-00

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