MAPK8基因详情-基因数据库-基因云馆

MAPK8 (mitogen-activated protein kinase 8)

symbol:: MAPK8
locus group:: protein-coding gene
location:: 10q11.22
gene_family:: Mitogen-activated protein kinases
alias symbol:: JNK|JNK1|SAPK1
alias name:: JUN N-terminal kinase
entrez id:: 5599
ensembl gene id:: ENSG00000107643
ucsc gene id:: uc001jgn.5
refseq accession:: NM_001278547
hgnc_id:: HGNC:6881
approved reserved:: 1998-04-28

10q11.22

MAPK8（丝裂原活化蛋白激酶8）也称为JNK1（c-Jun N端激酶1），属于MAPK（丝裂原活化蛋白激酶）家族中的JNK亚家族。该基因编码的蛋白是一种丝氨酸/苏氨酸激酶，在细胞应激反应、炎症、凋亡、增殖和分化等过程中发挥关键作用。MAPK8主要通过磷酸化转录因子（如c-Jun、ATF2）调控基因表达，从而影响细胞对压力、紫外线辐射或细胞因子的反应。其活性受上游激酶MKK4和MKK7的调控。MAPK8基因突变可能导致激酶活性异常，与多种疾病相关，包括神经退行性疾病（如阿尔茨海默病）、炎症性疾病和癌症。过表达MAPK8会增强细胞凋亡和炎症反应，可能促进肿瘤发生或神经细胞死亡；而表达降低则可能削弱细胞对压力的应对能力，影响发育和免疫反应。MAPK家族成员均参与信号转导，通过三级激酶级联（MAPKKK-MAPKK-MAPK）传递外界刺激至细胞核。JNK亚家族（包括MAPK8、MAPK9、MAPK10）主要响应应激信号，具有相似的结构域和激活机制。研究表明，MAPK8在肝脏代谢、胰岛素抵抗和肥胖中也起调节作用，其抑制剂正在被研究作为潜在的治疗药物。

中文English

无

OMIM数据库中对MAPK8基因的介绍 Wikipedia数据库中对MAPK8基因的介绍

MAPK8基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV
41CAAYDAILER NVAIKKLSRP FQNQTHAKRA YRELVLMKCV
81
NHKNIIGLL NVFTPQKSLE EFQDVYIVME LMDANLCQVI
121QMELDHERMS YLLYQMLCGI KHLHSAGIIH RDLKPSNIVV
161K
SDCTLKIL DFGLARTAGT SFMMTPYVVT RYYRAPEVIL
201GMGYKENVDL WSVGCIMGEM VCHKILFPGR DYIDQWNKVI
241EQ
LGTPCPE FMKKLQPTVR TYVENRPKYA GYSFEKLFPD
281VLFPADSEHN KLKASQARDL LSKMLVIDAS KRISVDEALQ
321HPY
INVWYD PSEAEAPPPK IPDKQLDERE HTIEEWKELI
361YKEVMDLEER TKNGVIRGQP SPLGAAVING SQHPSSSSSV
401NDVS
SMSTD PTLASDTDSS LEAAAGPLGC CR

结构预测来自 AlphaFold DB（UniProt: P45983），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

MAPK8基因的碱基突变：仅显示部分snp

rs8428 rs9284 rs1048693 rs1062225 rs1542153 rs2289807 rs2889610 rs4281444 rs4838590 rs7085678 rs7086275 rs7896768 rs10508902 rs10508903 rs11101319 rs11101320 rs11101321

MAPK8基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GACGCCTTATGTAGTGACTC

TTTCCCATTCTTCCTCCGT

AGAATGTCCTACCTTCTCTATCAG

TACTGGGCTTTAAGTCCCG

ACTTAAAGCCAGTCAGGCA

AGAGCTTCATCTACAGAGATCC

CGCCTTATGTAGTGACTCG

CACAGACCATAAATCCACGT

CGCCTTATGTAGTGACTCG

CACAGACCATAAATCCACGT

GGTACAGATCATATTGATCAGTGG

GTCCTTACTGTTGGTTGCA

AGGAATAGTATGCGCAGCT

TGATTCTGAAATGGTCGGC

AGCCTGGAATATACTTCTTGGT

AATTGTTGTCACGCTTGCT

ACGCCTTATGTAGTGACTCG

TTGTGTTCTGAGTCAGCGT

CCCTCTCCTTTAGGTGCAG

CGGATCTGTTGACATTGAAGAC

转录因子

影响基因

影响类型

参考文献链接（PubMed）

E2F1

MAPK8

Unknown

20800677

E2F3

MAPK8

Unknown

20800677

HSF2

MAPK8

Repression

11557063

JUN

MAPK8

Activation

19324081

JUN

MAPK8

Unknown

16397260

MAPK8基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

MAPK8基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000165

A6NF29 (UniProtKB)

IEA

GO:0004707

A6NF29 (UniProtKB)

IEA

GO:0005524

A6NF29 (UniProtKB)

IEA

GO:0005622

A6NF29 (UniProtKB)

IEA

GO:0000165

C9J762 (UniProtKB)

IEA

GO:0004707

C9J762 (UniProtKB)

IEA

GO:0005524

C9J762 (UniProtKB)

IEA

GO:0005622

C9J762 (UniProtKB)

IEA

GO:0000165

C9JWQ4 (UniProtKB)

IEA

GO:0004707

C9JWQ4 (UniProtKB)

IEA

GO:0005524

C9JWQ4 (UniProtKB)

IEA

GO:0005622

C9JWQ4 (UniProtKB)

IEA

GO:0004674

P45983 (UniProtKB)

IDA

GO:0004674

P45983 (UniProtKB)

IDA

GO:0004674

P45983 (UniProtKB)

IDA

GO:0004674

P45983 (UniProtKB)

IDA

GO:0004705

P45983 (UniProtKB)

IDA

GO:0004705

P45983 (UniProtKB)

IDA

GO:0004705

P45983 (UniProtKB)

TAS

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005515

P45983 (UniProtKB)

IPI

GO:0005524

P45983 (UniProtKB)

IEA

GO:0005634

P45983 (UniProtKB)

IDA

GO:0005654

P45983 (UniProtKB)

TAS

GO:0005654

P45983 (UniProtKB)

TAS

GO:0005654

P45983 (UniProtKB)

TAS

GO:0005654

P45983 (UniProtKB)

TAS

GO:0005654

P45983 (UniProtKB)

TAS

GO:0005739

P45983 (UniProtKB)

IEA

GO:0005829

P45983 (UniProtKB)

TAS

GO:0005829

P45983 (UniProtKB)

TAS

GO:0005829

P45983 (UniProtKB)

TAS

GO:0005829

P45983 (UniProtKB)

TAS

GO:0005829

P45983 (UniProtKB)

TAS

GO:0005829

P45983 (UniProtKB)

TAS

GO:0005829

P45983 (UniProtKB)

TAS

GO:0005829

P45983 (UniProtKB)

TAS

GO:0006468

P45983 (UniProtKB)

IMP

GO:0006950

P45983 (UniProtKB)

TAS

GO:0007254

P45983 (UniProtKB)

IDA

GO:0007254

P45983 (UniProtKB)

TAS

GO:0007258

P45983 (UniProtKB)

IDA

GO:0007258

P45983 (UniProtKB)

IDA

GO:0009411

P45983 (UniProtKB)

IDA

GO:0010628

P45983 (UniProtKB)

IMP

GO:0016241

P45983 (UniProtKB)

TAS

GO:0016301

P45983 (UniProtKB)

TAS

GO:0016301

P45983 (UniProtKB)

TAS

GO:0018105

P45983 (UniProtKB)

IDA

GO:0018105

P45983 (UniProtKB)

IDA

GO:0018105

P45983 (UniProtKB)

IDA

GO:0018107

P45983 (UniProtKB)

IMP

GO:0018107

P45983 (UniProtKB)

IDA

GO:0019899

P45983 (UniProtKB)

IPI

GO:0031063

P45983 (UniProtKB)

IEA

GO:0031281

P45983 (UniProtKB)

IMP

GO:0032091

P45983 (UniProtKB)

IDA

GO:0032880

P45983 (UniProtKB)

IDA

GO:0035033

P45983 (UniProtKB)

IMP

GO:0038095

P45983 (UniProtKB)

TAS

GO:0042752

P45983 (UniProtKB)

ISS

GO:0042826

P45983 (UniProtKB)

IPI

GO:0043065

P45983 (UniProtKB)

TAS

GO:0043066

P45983 (UniProtKB)

IDA

GO:0043066

P45983 (UniProtKB)

IDA

GO:0048511

P45983 (UniProtKB)

IEA

GO:0051090

P45983 (UniProtKB)

TAS

GO:0051247

P45983 (UniProtKB)

IMP

GO:0071222

P45983 (UniProtKB)

IDA

GO:0071260

P45983 (UniProtKB)

IEP

GO:0090045

P45983 (UniProtKB)

IMP

GO:1900740

P45983 (UniProtKB)

TAS

GO:1900740

P45983 (UniProtKB)

TAS

可能调控 MAPK8基因的相关microRNA：

hsa-miR-10a hsa-miR-125a-5p hsa-miR-140-3p hsa-miR-193b hsa-miR-33a hsa-miR-421 hsa-miR-101 hsa-miR-10b hsa-miR-10b* hsa-miR-126

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4141 Protein processing in endoplasmic reticulum [PATH:hsa04141]
4014 Ras signaling pathway [PATH:hsa04014]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4310 Wnt signaling pathway [PATH:hsa04310]
4668 TNF signaling pathway [PATH:hsa04668]
4068 FoxO signaling pathway [PATH:hsa04068]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4024 cAMP signaling pathway [PATH:hsa04024]
4510 Focal adhesion [PATH:hsa04510]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4621 NOD-like receptor signaling pathway [PATH:hsa04621]
4622 RIG-I-like receptor signaling pathway [PATH:hsa04622]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4910 Insulin signaling pathway [PATH:hsa04910]
4920 Adipocytokine signaling pathway [PATH:hsa04920]
4912 GnRH signaling pathway [PATH:hsa04912]
4914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
4917 Prolactin signaling pathway [PATH:hsa04917]
4728 Dopaminergic synapse [PATH:hsa04728]
4723 Retrograde endocannabinoid signaling [PATH:hsa04723]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750]
4380 Osteoclast differentiation [PATH:hsa04380]
5200 Pathways in cancer [PATH:hsa05200]
5231 Choline metabolism in cancer [PATH:hsa05231]
5210 Colorectal cancer [PATH:hsa05210]
5212 Pancreatic cancer [PATH:hsa05212]
4930 Type II diabetes mellitus [PATH:hsa04930]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
5132 Salmonella infection [PATH:hsa05132]
5131 Shigellosis [PATH:hsa05131]
5133 Pertussis [PATH:hsa05133]
5152 Tuberculosis [PATH:hsa05152]
5166 HTLV-I infection [PATH:hsa05166]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]
5168 Herpes simplex infection [PATH:hsa05168]
5169 Epstein-Barr virus infection [PATH:hsa05169]
5145 Toxoplasmosis [PATH:hsa05145]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

名称
Activated TLR4 signalling
Activation of BH3-only proteins
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
Activation of the AP-1 family of transcription factors
Apoptosis
Cell death signalling via NRAGE, NRIF and NADE
Cell-Cell communication
Cellular responses to stress
Cellular Senescence
DSCAM interactions
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
Immune System
Innate Immune System
Intrinsic Pathway for Apoptosis
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
MAP kinase activation in TLR cascade
MAPK targets/ Nuclear events mediated by MAP kinases
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88-independent TLR3/TLR4 cascade
MyD88:Mal cascade initiated on plasma membrane
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
p75 NTR receptor-mediated signalling
Programmed Cell Death
Signal Transduction
Signalling by NGF
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor 9 (TLR9) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll-Like Receptors Cascades
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 Mediated Induction of proinflammatory cytokines
TRIF-mediated TLR3/TLR4 signaling

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Reperfusion Injury	0.2	2	0	CTD_human_RGD
Dermatitis, Atopic	0.12	1	0	CTD_human
Precancerous Conditions	0.12	1	0	CTD_human
Liver Failure, Acute	0.12	1	0	CTD_human
Neoplastic Cell Transformation	0.12	1	0	CTD_human
Stomach Neoplasms	0.12	1	0	CTD_human
Myocardial Reperfusion Injury	0.08	2	0	RGD
Hypertensive disease	0.08	1	0	RGD
Anti-Glomerular Basement Membrane Disease	0.08	1	0	RGD
Cerebrovascular accident	0.08	1	0	RGD

MsrB2 deficiency amplifies ECM-driven cardiac fibrosis under hypertensive stress.

Yun JH, Cho S, Lee JY, Kim S, Lee SH Front Physiol IF: 4.134 None

Genetic Modulation of Wound Healing Pathways and Postoperative Risk in Plastic and Reconstructive Surgery: A Cohort Study.

Sydorchuk L, Gumennyi R, Sydorchuk A, Batih I, Vasiuk V, Sydorchuk R, Kamyshna I, Petakh P, Halabitska I, Kamyshnyi O J Clin Med 2026-04-07

Exploring potential phytocompounds from black cumin as drug molecules against SARS-CoV-2 infections through bioinformatics analysis.

Ali MA, Sheikh H, Reza MS, Paul TR, Noor T, Kumar N, Bhat MA, Mollah MNH PLoS One IF: 2.6 None

Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway.

Shi ZY, Ding ZR, Huang YL, Lei YR, Huang HB, Qing Y, Deng MR, Lu XM, Dong XD, Xia LJ, Xu S, Zhong XG, Li L, Kong FB, Wang XT Oncol Rep IF: 4.7 2026-05-00

Inflammaging-Induced Bioenergetic Gap Exhausts Pulmonary Nucleotide Pools to Exacerbate SARS-CoV-2 Outcomes in Early Stage Aging.

Li X, Wu ZE, Wang X, Luo F, Deng C, Chen Y, Wan H, Tang X, Zhang Y, Shi P, Wu Z, Ning C, Yang W, Yang H, Liu J, Li F J Proteome Res IF: 3.8 2026-04-03

Disrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia.

Liu H, Wang H J Mol Histol IF: 2.6 2026-03-23

Integrating metabolomics and molecular dynamics simulation to elucidate the anti-atherosclerotic mechanisms of Gynostemma pentaphyllum.

Bu W, Xia Y, Qiu J, Zong W, Zhu S, Du Y, Liu Y, Yu Q, Huang X, Geng Z, Liu F Arch Biochem Biophys IF: 3.5 2026-06-00

Network pharmacology analysis and experimental validation of modified Taohong Siwu decoction against atherosclerosis.

Shao C, Meng W, Ning K, Huang M, Li H, Cai H, Xu Y, Zuo T, Guo HD In Vitro Cell Dev Biol Anim IF: 2.0 2026-04-00

The Impact of Surgical Trauma-Activated Platelet-Rich Fibrin on Mesenchymal Stromal Cells In Vitro.

Verboket RD, Usov L, Bohl I, Neijhoft J, Penna-Martinez M, Marzi I, Henrich D Cells 2026-05-21

Kaempferol alleviates copper-induced nephrotoxicity by targeting MAPK8 and CASP3 in broiler: Insights from network toxicology, network pharmacology, molecular docking and dynamics simulation.

Wang J, Han M, Yu J, Chen B, Guo S, Wu Z, Huang H, Tang Z, Liao J, Guo J J Trace Elem Med Biol IF: 4.1 2026-06-00

查看更多相关文献 »

评论加载中...

登录后即可发表评论登录注册

联系地址

山东省济南市章丘区文博路2号

齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号

大学科技园北区F座4单元2楼

电话： 0531-88819269

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

商务邮箱

E-mail: [email protected]

MAPK8 (mitogen-activated protein kinase 8)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

联系地址

微信公众号