MIR101-1 (microRNA 101-1)

Gene Basic Information

Gene Basic Information

symbol:
MIR101-1
locus group:
non-coding RNA
location:
1p31.3
gene_family:
MicroRNAs
alias symbol:
hsa-mir-101-1
alias name:
None
entrez id:
406893
ensembl gene id:
ENSG00000199135
ucsc gene id:
uc001dbx.3
refseq accession:
NR_029516
hgnc_id:
HGNC:31488
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

1p31.3

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR101-1     Wikipedia entry for MIR101-1

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR101-1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR101-1:           Showing partial SNPs
rs489500       rs492218       rs1011210       rs1497054       rs7536540       rs34865486       rs56394547       rs74626544       rs76885111       rs77857288       rs79900790       rs113318787       rs116139848       rs137876968       rs141630323       rs145290264       rs150129220      

Gene Expression

Gene Expression

Tissue expression of MIR101-1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TGGCTCAGTTATCACAGTG
57
TCAGTTATCACAGTACTGTACC
57
CTGGCTCAGTTATCACAGTG
58
CAGTTATCACAGTACTGTACCT
57
GCTCAGTTATCACAGTGCT
57
CTTCAGTTATCACAGTACTGTACC
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR101-1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR101-1:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR101-1:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Liver Cirrhosis 0.000271442 1 1 BeFree
Liver carcinoma 0.000271442 1 1 BeFree

Related Publications

Related Publications

Two Different Serum MiRNA Signatures Correlate with the Clinical Outcome and Histological Subtype in Pleural Malignant Mesothelioma Patients.
Lamberti Monica, Capasso Rosanna, Lombardi Angela, Di Domenico Marina, Fiorelli Alfonso, Feola Antonia, Perna Alessandra F, Santini Mario, Caraglia Michele, Ingrosso Diego PLoS One IF: 2.6 2016-05-10

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