MIR126 (microRNA 126)

Gene Basic Information

Gene Basic Information

symbol:
MIR126
locus group:
non-coding RNA
location:
9q34.3
gene_family:
MicroRNAs
alias symbol:
hsa-mir-126
alias name:
None
entrez id:
406913
ensembl gene id:
ENSG00000199161
ucsc gene id:
uc022bps.1
refseq accession:
NR_029695
hgnc_id:
HGNC:31508
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

9q34.3

Gene Summary

Gene Summary

ChineseEnglish

MicroRNAs (miRNAs) are short (20–24 nucleotide) noncoding RNAs that post-transcriptionally regulate gene expression in multicellular organisms by affecting mRNA stability and translation. They are transcribed by RNA polymerase II as parts of capped and polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. Pri-miRNAs are cleaved by the RNase III enzyme Drosha to produce an approximately 70-nucleotide stem-loop precursor miRNA (pre-miRNA), which is further processed by cytoplasmic Dicer to yield mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing and most often leads to translational repression or destabilization of the target mRNA. RefSeq represents the predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]

OMIM entry for MIR126     Wikipedia entry for MIR126

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR126:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR126:           Showing partial SNPs
rs1140713       rs2297534       rs2297535       rs2297536       rs2297537       rs2297538       rs4636297       rs7030829       rs7846878       rs34142075       rs34271855       rs35863900       rs57311093       rs61731643       rs61736886       rs78242242       rs112082874      

Gene Expression

Gene Expression

Tissue expression of MIR126:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR126 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR126:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR126:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Non-Small Cell Lung Carcinoma 0.122714419 11 0 BeFree_CTD_human
Malignant mesothelioma 0.120814326 3 0 BeFree_CTD_human
Mammary Neoplasms 0.120542884 3 0 BeFree_CTD_human
Myocardial Reperfusion Injury 0.12 1 0 CTD_human
Neoplasm Metastasis 0.004614512 17 0 BeFree
Lung Neoplasms 0.002995792 2 0 BeFree_LHGDN
Colorectal Cancer 0.002171535 8 0 BeFree
Colorectal Carcinoma 0.001900093 7 0 BeFree
Stomach Carcinoma 0.001900093 7 0 BeFree
Malignant neoplasm of breast 0.001900093 7 0 BeFree

Related Publications

Related Publications

miR126-mediated alteration of vascular integrity in Rett syndrome.
Osaki T, Wan Z, Haratani K, Jin Y, Campisi M, Barbie DA, Kamm RD, Sur M Mol Psychiatry IF: 10.4 2026-07-00
Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function.
Hakimzadeh Nazanin, Nossent A Yaël, van der Laan Anja M, Schirmer Stephan H, de Ronde Maurice W J, Pinto-Sietsma Sara-Joan, van Royen Niels, Quax Paul H A, Hoefer Imo E, Piek Jan J PLoS One IF: 2.6 2016-05-19
A novel pathway of cellular activation mediated by antiphospholipid antibody-induced extracellular vesicles.
Wu M, Barnard J, Kundu S, McCrae K R J Thromb Haemost IF: 5.2 2016-08-04
Methylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma.
Andersen Morten, Trapani Davide, Ravn Jesper, Sørensen Jens Benn, Andersen Claus Bøgelund, Grauslund Morten, Santoni-Rugiu Eric Anticancer Res IF: 1.8 2016-02-08
EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay.
Takeuchi Kimio, Yanai Ryoji, Kumase Fumiaki, Morizane Yuki, Suzuki Jun, Kayama Maki, Brodowska Katarzyna, Nakazawa Mitsuru, Miller Joan W, Connor Kip M, Vavvas Demetrios G PLoS One IF: 2.6 2015-12-14
Egfl7 is differentially expressed in arteries and veins during retinal vascular development.
Poissonnier Loïc, Villain Gaëlle, Soncin Fabrice, Mattot Virginie PLoS One IF: 2.6 2015-02-09
miR126-5p repression of ALCAM and SetD5 in endothelial cells regulates leucocyte adhesion and transmigration.
Poissonnier Loïc, Villain Gaëlle, Soncin Fabrice, Mattot Virginie Cardiovasc Res IF: 12.5 2015-03-02
MicroRNA-126 suppresses mesothelioma malignancy by targeting IRS1 and interfering with the mitochondrial function.
Tomasetti Marco, Nocchi Linda, Staffolani Sara, Manzella Nicola, Amati Monica, Goodwin Jacob, Kluckova Katarina, Nguyen Maria, Strafella Elisabetta, Bajzikova Martina, Peterka Martin, Lettlova Sandra, Truksa Jaroslav, Lee Wan, Dong Lan-Feng, Santarelli Lory, Neuzil Jiri Antioxid Redox Signal IF: 6.8 2015-07-06
Epidermal growth factor-like domain 7 predicts response to first-line chemotherapy and bevacizumab in patients with metastatic colorectal cancer.
Hansen Torben Frøstrup, Nielsen Boye Schnack, Sørensen Flemming Brandt, Johnsson Anders, Jakobsen Anders Mol Cancer Ther IF: 6.9 2015-11-17
Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens.
Kubo Eri, Hasanova Nailia, Sasaki Hiroshi, Singh Dhirendra P J Cell Mol Med IF: 4.7 2014-04-29

Related Services

Related Services

Comments

Comments

Loading comments...

Log in to post comments Log In Sign Up

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2