MIR129-2Gene Detail-Gene Database-Genelibs

MIR129-2 (microRNA 129-2)

symbol:: MIR129-2
locus group:: non-coding RNA
location:: 11p11.2
gene_family:: MicroRNAs
alias symbol:: hsa-mir-129-2
alias name:: None
entrez id:: 406918
ensembl gene id:: ENSG00000199077
ucsc gene id:: uc001mxo.2
refseq accession:: NR_029697
hgnc_id:: HGNC:31513
approved reserved:: 2004-04-23

11p11.2

ChineseEnglish

MIR129-2是microRNA基因家族中的一员，属于MIR129基因家族，该家族包括MIR129-1和MIR129-2两个成员。microRNA是一类短的非编码RNA分子，通常由约22个核苷酸组成，主要功能是通过与靶基因的mRNA结合来调控基因表达，从而影响多种生物学过程，如细胞增殖、分化、凋亡和代谢等。MIR129-2位于人类11号染色体上，其表达产物miR-129在多种组织中均有表达，尤其在脑组织中表达较高，表明它可能在神经系统发育和功能中发挥重要作用。miR-129的靶基因包括许多与细胞周期调控、肿瘤发生和神经发育相关的基因，例如SOX4、CDK6和E2F3等。研究表明，MIR129-2的突变或表达异常可能与多种疾病相关，特别是癌症和神经退行性疾病。在多种肿瘤中，如胃癌、结直肠癌和胶质瘤等，MIR129-2的表达水平显著降低，这种低表达可能导致其靶基因的过度激活，从而促进肿瘤细胞的增殖和侵袭。相反，过表达miR-129可以抑制肿瘤细胞的生长并诱导凋亡，显示出其潜在的抑癌作用。此外，MIR129-2在阿尔茨海默病等神经退行性疾病中也表现出表达异常，可能通过调控神经元存活和突触可塑性相关基因参与疾病进程。MIR129基因家族的共性在于它们编码的miRNA在序列上高度保守，并且在多种生物过程中发挥重要的调控作用，尤其是在肿瘤抑制和神经系统中。MIR129-2的表达水平变化不仅影响其直接靶基因的功能，还可能通过调控信号通路（如Wnt/β-catenin和PI3K/AKT通路）产生广泛的生物学效应。因此，MIR129-2及其产物miR-129在疾病诊断和治疗中具有潜在的应用价值，可能成为未来研究的重要靶点。

微RNA（miRNAs）是短（20-24核苷酸）非编码由既影响稳定性和mRNA的翻译参与基因表达的转录后调控在多细胞生物体的RNA。的miRNA通过RNA聚合酶II转录为加盖并聚腺苷酸化初级转录物的部分（PRI-微RNA），可以是任一蛋白质编码或非编码。初级转录由酶Drosha核糖核酸酶III酶裂解以产生约70个核苷酸茎 - 环前体miRNA（前miRNA），这是由胞质Dicer的核糖核酸酶进一步切割以产生成熟miRNA和反义miRNA的星（miRNA的* ）产品。成熟miRNA掺入RNA诱导的沉默复合物（RISC），其通过不完全碱基配对识别靶mRNA与所述miRNA和最通常导致翻译抑制或去稳定化的靶mRNA。所述的RefSeq表示预测的微RNA茎环。 [由RefSeq的，2009年09月提供]

MicroRNAs (miRNAs) are short (20–24 nucleotide) noncoding RNAs that regulate gene expression post-transcriptionally in multicellular organisms by affecting mRNA stability and translation. miRNAs are transcribed by RNA polymerase II as parts of capped and polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. Pri-miRNAs are cleaved by the RNase III enzyme Drosha to produce approximately 70-nucleotide stem-loop precursor miRNAs (pre-miRNAs), which are further processed by cytoplasmic Dicer into mature miRNAs and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing and usually leads to translational repression or destabilization of the target mRNA. RefSeq represents the predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]

OMIM entry for MIR129-2 Wikipedia entry for MIR129-2

Nucleotide sequence of MIR129-2:[NCBI]

Loading Gene Browser...

SNP variants of MIR129-2: Showing partial SNPs

rs1483131 rs1552204 rs2035445 rs2625386 rs2679060 rs4755717 rs11820132 rs67580381 rs71490035 rs79321412 rs111261832 rs117003502 rs117604922 rs138009403 rs139083497 rs139964471 rs141461882

Tissue expression of MIR129-2: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

No data available

Subcellular localization of MIR129-2 (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for MIR129-2:

microRNAs potentially regulating MIR129-2:

Loading…

Interacting Gene	Interaction	Source/Score

KEGG

Name
5206 MicroRNAs in cancer [PATH:hsa05206]

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Stomach Carcinoma	0.000814326	3	0	BeFree
Malignant neoplasm of stomach	0.000814326	3	0	BeFree
Uterine Corpus Cancer	0.000814326	3	0	BeFree
Malignant neoplasm of endometrium	0.000814326	3	0	BeFree
Endometrial Carcinoma	0.000814326	3	0	BeFree
Carcinogenesis	0.000542884	2	0	BeFree
Liver carcinoma	0.000542884	2	0	BeFree
Myeloid Leukemia, Chronic	0.000271442	1	0	BeFree
Colorectal Cancer	0.000271442	1	0	BeFree
Clear-cell metastatic renal cell carcinoma	0.000271442	1	0	BeFree

Supervising the recurrence of pancreatic ductal adenocarcinoma using CtDNA-based MIR129-2 methylation detection.

Wang WQ, Xu ZH, He TC, Wang HY, Xie YQ, He JY, Pu N, Li C, Pan XB, Li J, Cao ZB, Ding GH, Wang XA, Xu HX, Liu XT, Liu L Int J Surg IF: 9.0 2026-01-01

[Coordinated Expression and Methylation of microRNAs: Role in Common Biological Processes and Signaling Pathways in Breast Cancer].

Filippova EA, Pronina IV, Loginov VI, Kazubskaya TP, Braga EA Mol Biol (Mosk) 2025-00-00

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma.

Yadavilli Sridevi, Scafidi Joseph, Becher Oren J, Saratsis Amanda M, Hiner Rebecca L, Kambhampati Madhuri, Mariarita Santi, MacDonald Tobey J, Codispoti Kari-Elise, Magge Suresh N, Jaiswal Jyoti K, Packer Roger J, Nazarian Javad Oncotarget IF: 5.168 2016-04-05

The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine.

Strickland Eric R, Woller Sarah A, Hook Michelle A, Grau James W, Miranda Rajesh C Neurochem Int IF: 5.5 2015-06-04

Regulatory effects of intermittent noxious stimulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion.

Strickland Eric R, Woller Sarah A, Garraway Sandra M, Hook Michelle A, Grau James W, Miranda Rajesh C Front Neural Circuits IF: 3.005 2015-05-15

Genome-wide association study identifies three novel loci for type 2 diabetes.

Hara Kazuo, Fujita Hayato, Johnson Todd A, Yamauchi Toshimasa, Yasuda Kazuki, Horikoshi Momoko, Peng Chen, Hu Cheng, Ma Ronald C W, Imamura Minako, Iwata Minoru, Tsunoda Tatsuhiko, Morizono Takashi, Shojima Nobuhiro, So Wing Yee, Leung Ting Fan, Kwan Patrick, Zhang Rong, Wang Jie, Yu Weihui, Maegawa Hiroshi, Hirose Hiroshi, , Kaku Kohei, Ito Chikako, Watada Hirotaka, Tanaka Yasushi, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Jia Weiping, Chan Juliana C N, Teo Yik Ying, Shyong Tai E, Kamatani Naoyuki, Kubo Michiaki, Maeda Shiro, Kadowaki Takashi Hum Mol Genet IF: 3.1 2014-08-04

Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.

Qin Wenyi, Zhang Ke, Clarke Kaitlin, Weiland Timothy, Sauter Edward R Nutr Cancer IF: 2.7 2014-10-15

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Loth Daan W, Soler Artigas María, Gharib Sina A, Wain Louise V, Franceschini Nora, Koch Beate, Pottinger Tess D, Smith Albert Vernon, Duan Qing, Oldmeadow Chris, Lee Mi Kyeong, Strachan David P, James Alan L, Huffman Jennifer E, Vitart Veronique, Ramasamy Adaikalavan, Wareham Nicholas J, Kaprio Jaakko, Wang Xin-Qun, Trochet Holly, Kähönen Mika, Flexeder Claudia, Albrecht Eva, Lopez Lorna M, de Jong Kim, Thyagarajan Bharat, Alves Alexessander Couto, Enroth Stefan, Omenaas Ernst, Joshi Peter K, Fall Tove, Viñuela Ana, Launer Lenore J, Loehr Laura R, Fornage Myriam, Li Guo, Wilk Jemma B, Tang Wenbo, Manichaikul Ani, Lahousse Lies, Harris Tamara B, North Kari E, Rudnicka Alicja R, Hui Jennie, Gu Xiangjun, Lumley Thomas, Wright Alan F, Hastie Nicholas D, Campbell Susan, Kumar Rajesh, Pin Isabelle, Scott Robert A, Pietiläinen Kirsi H, Surakka Ida, Liu Yongmei, Holliday Elizabeth G, Schulz Holger, Heinrich Joachim, Davies Gail, Vonk Judith M, Wojczynski Mary, Pouta Anneli, Johansson Asa, Wild Sarah H, Ingelsson Erik, Rivadeneira Fernando, Völzke Henry, Hysi Pirro G, Eiriksdottir Gudny, Morrison Alanna C, Rotter Jerome I, Gao Wei, Postma Dirkje S, White Wendy B, Rich Stephen S, Hofman Albert, Aspelund Thor, Couper David, Smith Lewis J, Psaty Bruce M, Lohman Kurt, Burchard Esteban G, Uitterlinden André G, Garcia Melissa, Joubert Bonnie R, McArdle Wendy L, Musk A Bill, Hansel Nadia, Heckbert Susan R, Zgaga Lina, van Meurs Joyce B J, Navarro Pau, Rudan Igor, Oh Yeon-Mok, Redline Susan, Jarvis Deborah L, Zhao Jing Hua, Rantanen Taina, O'Connor George T, Ripatti Samuli, Scott Rodney J, Karrasch Stefan, Grallert Harald, Gaddis Nathan C, Starr John M, Wijmenga Cisca, Minster Ryan L, Lederer David J, Pekkanen Juha, Gyllensten Ulf, Campbell Harry, Morris Andrew P, Gläser Sven, Hammond Christopher J, Burkart Kristin M, Beilby John, Kritchevsky Stephen B, Gudnason Vilmundur, Hancock Dana B, Williams O Dale, Polasek Ozren, Zemunik Tatijana, Kolcic Ivana, Petrini Marcy F, Wjst Matthias, Kim Woo Jin, Porteous David J, Scotland Generation, Smith Blair H, Viljanen Anne, Heliövaara Markku, Attia John R, Sayers Ian, Hampel Regina, Gieger Christian, Deary Ian J, Boezen H Marike, Newman Anne, Jarvelin Marjo-Riitta, Wilson James F, Lind Lars, Stricker Bruno H, Teumer Alexander, Spector Timothy D, Melén Erik, Peters Marjolein J, Lange Leslie A, Barr R Graham, Bracke Ken R, Verhamme Fien M, Sung Joohon, Hiemstra Pieter S, Cassano Patricia A, Sood Akshay, Hayward Caroline, Dupuis Josée, Hall Ian P, Brusselle Guy G, Tobin Martin D, London Stephanie J Nat Genet IF: 25.5 2014-09-04

Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression.

Jeon Hye-Min, Kim Sung-Hak, Jin Xun, Park Jong Bae, Kim Se Hoon, Joshi Kaushal, Nakano Ichiro, Kim Hyunggee Cancer Res IF: 22.6 2014-12-15

Epigenetic inactivation of the MIR129-2 in hematological malignancies.

Wong Kwan-Yeung, Yim Rita Lok-Hay, Kwong Yok-Lam, Leung Chung-Ying, Hui Pak-Kwan, Cheung Florence, Liang Raymond, Jin Dong-Yan, Chim Chor-Sang J Hematol Oncol IF: 6.350 2013-07-25

View more publications »

Loading comments...

Log in to post comments Log In Sign Up

MIR129-2 (microRNA 129-2)

Gene Basic Information

Gene Basic Information

Chromosome Location

Chromosome Location

Gene Summary

Gene Summary

Gene Sequence

Gene Sequence

Gene Variants

Gene Variants

Gene Expression

Gene Expression

Gene Primers

Gene Primers

Transcription Factors

Transcription Factors

No data available

Gene Ontology

Related microRNA

Related microRNA

Gene Interactions

Gene Interactions

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Related Publications

Related Publications

Related Services

Related Services

Comments

Comments

Contact

WeChat Official Account