MIR133A1 (microRNA 133a-1)

Gene Basic Information

Gene Basic Information

symbol:
MIR133A1
locus group:
non-coding RNA
location:
18q11.2
gene_family:
MicroRNAs
alias symbol:
hsa-mir-133a-1
alias name:
None
entrez id:
406922
ensembl gene id:
ENSG00000283927
ucsc gene id:
uc021uib.1
refseq accession:
NR_029675
hgnc_id:
HGNC:31517
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

18q11.2

Gene Summary

Gene Summary

ChineseEnglish

MicroRNAs (miRNAs) are short (20–24 nucleotides) noncoding RNAs that participate in post-transcriptional regulation of gene expression in multicellular organisms by affecting mRNA stability and translation. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs), which can be protein-coding or noncoding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nucleotide stem-loop precursor miRNA (pre-miRNA), which is further cleaved by cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. RefSeq represents a predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]

OMIM entry for MIR133A1     Wikipedia entry for MIR133A1

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR133A1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR133A1:           Showing partial SNPs
rs2155975       rs6508626       rs8089787       rs9948906       rs75017772       rs111418677       rs112388603       rs115634447       rs139102927       rs139563822       rs141455659       rs146258714       rs149757314       rs150570870       rs182673735       rs183939400       rs184550893      

Gene Expression

Gene Expression

Tissue expression of MIR133A1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ACAATGCTTTGCTAGAGCT
57
GGGACCAAATCCATTGAAGAG
59
ACAATGCTTTGCTAGAGCTG
59
GGGACCAAATCCATTGAAGAG
59
AATGGAACCAAATCGCCTC
59
ATGCATAGCTACAGCTGGT
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR133A1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR133A1:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR133A1:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Parkinson Disease 0.002367032 1 0 GAD

Related Publications

Related Publications

Could MicroRNA polymorphisms influence warfarin dosing? A pharmacogenetics study on mir133 genes.
Ciccacci Cinzia, Rufini Sara, Politi Cristina, Novelli Giuseppe, Forte Vittorio, Borgiani Paola Thromb Res IF: 3.4 2016-05-03
A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance.
Ohanian Monique, Humphreys David T, Anderson Elizabeth, Preiss Thomas, Fatkin Diane BMC Genet IF: 2.9 2013-05-22

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