MIR133A1HG (MIR133A1 host gene)

Gene Basic Information

Gene Basic Information

symbol:
MIR133A1HG
locus group:
non-coding RNA
location:
18q11.2
gene_family:
alias symbol:
MIR1-2HG
alias name:
MIR1-2 host gene (non-protein codi…
entrez id:
102723167
ensembl gene id:
ENSG00000265142
ucsc gene id:
None
refseq accession:
NR_110369
hgnc_id:
HGNC:49594
approved reserved:
2014-01-21

Chromosome Location

Chromosome Location

18q11.2

Gene Summary

Gene Summary

MIR133A1HG（也称为LINC00961）是一个长链非编码RNA（lncRNA）基因，位于人类染色体18q11.2上。它最初被认为是MIR133A1基因的主转录本，但后来研究发现它本身具有独立的生物学功能。MIR133A1HG的主要功能是通过调控多种信号通路参与细胞增殖、分化、凋亡以及代谢过程。它在肌肉组织、心脏和骨骼肌中表达较高，尤其在肌肉发育和再生过程中发挥重要作用。MIR133A1HG的表达产物可以与蛋白质、RNA或DNA相互作用，从而影响基因表达和信号转导。例如，它通过抑制mTORC1信号通路调节自噬和肌肉再生，并在心脏肥大和心力衰竭中起保护作用。MIR133A1HG的突变或表达异常可能导致肌肉疾病、心血管疾病或代谢紊乱。研究发现，其表达降低与肌肉萎缩、心肌病和某些癌症（如肝癌和胃癌）的发生发展相关，而过表达可能通过抑制病理性心肌肥厚或促进肌肉再生发挥保护作用。MIR133A1HG属于长链非编码RNA基因家族，这类RNA通常不编码蛋白质，但可通过表观遗传调控、转录调控或作为竞争性内源RNA（ceRNA）参与多种生物学过程。该基因家族的共性包括在基因表达调控、细胞命运决定和疾病发生中起关键作用，且多数成员具有组织特异性表达模式。MIR133A1HG的深入研究有助于理解肌肉和心脏疾病的分子机制，并为相关治疗提供潜在靶点。

OMIM entry for MIR133A1HG     Wikipedia entry for MIR133A1HG

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR133A1HG:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR133A1HG:           Showing partial SNPs
rs2155975       rs3810042       rs4591246       rs6508626       rs8089787       rs9948906       rs9989532       rs35046389       rs45487599       rs61641899       rs72071759       rs74919332       rs75017772       rs75809473       rs77054963       rs78641532       rs111418677      

Gene Expression

Gene Expression

Tissue expression of MIR133A1HG:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GGATGTGACAAGAAATGCTG
58
AGAGAATCACATCAACAGCAG
59
TAAGTTAGCCTCGTAGTGACC
59
CAGAACCTCACCTTGTCAC
58
AGGTAGCTTCACTACAGCTC
59
AACACAGAACCTCACCCTG
60
GATGTGATTCTCTAGGTTACTACC
58
GTAGTCTGCTTCTAGATCCTG
57
AGTTAGCCTCGTAGTGACC
59
CACAGAACCTCACCTTGTC
58
CTGTTGATGTGATTCTCTAGGT
57
TGCTTCTAGATCCTGTAAGCT
58
TAAGTTAGCCTCGTAGTGACC
59
TTCAGCATTTCTTGTCACATCC
60
CTACAGCTCTACTATTTAATCCTGG
59
GAACACAGAACCTCACCCT
59
GCTGTTGATGTGATTCTCTAGG
59
CTTCTAGATCCTGTAAGCTTAGTG
58
ATAAGTTAGCCTCGTAGTGACC
60
TCAGCATTTCTTGTCACATCC
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR133A1HG (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR133A1HG:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR133A1HG:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

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