MIR133A2 (microRNA 133a-2)

Gene Basic Information

Gene Basic Information

symbol:
MIR133A2
locus group:
non-coding RNA
location:
20q13.33
gene_family:
MicroRNAs
alias symbol:
hsa-mir-133a-2
alias name:
None
entrez id:
406923
ensembl gene id:
ENSG00000284508
ucsc gene id:
uc011aal.1
refseq accession:
NR_029676
hgnc_id:
HGNC:31518
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

20q13.33

Gene Summary

Gene Summary

ChineseEnglish

MIR133A2 is a microRNA (miRNA) gene. miRNAs are short (20–24 nt) noncoding RNAs that participate in post-transcriptional regulation of gene expression in multicellular organisms by affecting both mRNA stability and translation. They are transcribed by RNA polymerase II as parts of capped and polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. Drosha ribonuclease III cleaves the primary transcript to produce an approximately 70-nucleotide stem-loop precursor miRNA (pre-miRNA), which cytoplasmic Dicer further cleaves to generate mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA, most commonly leading to translational inhibition or destabilization of the target mRNA. RefSeq represents the predicted microRNA

OMIM entry for MIR133A2     Wikipedia entry for MIR133A2

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR133A2:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR133A2:           Showing partial SNPs
rs4969521       rs4969522       rs4969523       rs4969530       rs4969531       rs6062235       rs6062249       rs6062250       rs6062251       rs6062253       rs6062254       rs6122008       rs6122009       rs6122010       rs6143047       rs7263047       rs7264564      

Gene Expression

Gene Expression

Tissue expression of MIR133A2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAACCAAATCGACTGTCCA
58
ATCAATGCACAGCTACAGC
59
GCCAAATGCTTTGCTAGAG
57
GACCAAATCCATTGGACAGTC
59
AGCCAAATGCTTTGCTAGAG
59
ACCAAATCCATTGGACAGTC
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR133A2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR133A2:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR133A2:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Parkinson Disease 0.002367032 1 0 GAD

Related Publications

Related Publications

Could MicroRNA polymorphisms influence warfarin dosing? A pharmacogenetics study on mir133 genes.
Ciccacci Cinzia, Rufini Sara, Politi Cristina, Novelli Giuseppe, Forte Vittorio, Borgiani Paola Thromb Res IF: 3.4 2016-05-03
A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance.
Ohanian Monique, Humphreys David T, Anderson Elizabeth, Preiss Thomas, Fatkin Diane BMC Genet IF: 2.9 2013-05-22

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