MIR135A1 (microRNA 135a-1)

Gene Basic Information

Gene Basic Information

symbol:
MIR135A1
locus group:
non-coding RNA
location:
3p21.2
gene_family:
MicroRNAs
alias symbol:
hsa-mir-135-1|hsa-mir-135a-1
alias name:
None
entrez id:
406925
ensembl gene id:
ENSG00000207926
ucsc gene id:
uc010hmf.3
refseq accession:
NR_029677
hgnc_id:
HGNC:31520
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

3p21.2

Gene Summary

Gene Summary

ChineseEnglish

MicroRNAs (miRNAs) are short, 20–24 nucleotide noncoding RNAs that participate in post-transcriptional gene regulation in multicellular organisms by affecting mRNA stability and translation. They are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. The primary transcript is cleaved by the RNase III enzyme Drosha to produce an approximately 70-nucleotide stem-loop precursor miRNA (pre-miRNA), which cytoplasmic Dicer further cleaves to generate mature miRNA and antisense miRNA star (miRNA*) products. Mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most often leads to translational inhibition or destabilization of the target mRNA. The RefSeq entry represents the predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]

OMIM entry for MIR135A1     Wikipedia entry for MIR135A1

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR135A1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR135A1:           Showing partial SNPs
rs3733063       rs11708811       rs11709104       rs12633181       rs55676974       rs72959335       rs75155826       rs77049753       rs78371237       rs111230618       rs114320703       rs114516529       rs115083870       rs138024670       rs138836181       rs139485909       rs142035206      

Gene Expression

Gene Expression

Tissue expression of MIR135A1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTCGCTGTTCTCTATGGCT
59
CCAATCCCTATATGAGTGAGC
58
CTCGCTGTTCTCTATGGCT
59
CCAATCCCTATATGAGTGAGCA
60
CTCGCTGTTCTCTATGGCT
59
CAATCCCTATATGAGTGAGCAG
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR135A1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR135A1:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR135A1:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Colorectal Neoplasms 0.00272435 1 0 LHGDN

Related Publications

Related Publications

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