MIR138-2 (microRNA 138-2)

Gene Basic Information

Gene Basic Information

symbol:
MIR138-2
locus group:
non-coding RNA
location:
16q13
gene_family:
MicroRNAs
alias symbol:
hsa-mir-138-2
alias name:
None
entrez id:
406930
ensembl gene id:
ENSG00000207649
ucsc gene id:
uc002ekc.4
refseq accession:
NR_029680
hgnc_id:
HGNC:31525
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

16q13

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR138-2     Wikipedia entry for MIR138-2

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR138-2:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR138-2:           Showing partial SNPs
rs1529930       rs8061693       rs9928011       rs12934576       rs35474169       rs35810185       rs71152210       rs75541152       rs76987351       rs77350480       rs77544870       rs78936631       rs80072323       rs113015675       rs113545870       rs115643379       rs116715247      

Gene Expression

Gene Expression

Tissue expression of MIR138-2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GCTGGTGTTGTGAATCAGG
59
CTGGTGTCGTGAAATAGCC
59
CTGGTGTTGTGAATCAGGC
59
CCTGGTGTCGTGAAATAGC
59
CTGGTGTTGTGAATCAGGC
59
CTGGTGTCGTGAAATAGCC
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR138-2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR138-2:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR138-2:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

Screening and confirmation of microRNA markers for forensic body fluid identification.
Wang Zheng, Zhang Ji, Luo Haibo, Ye Yi, Yan Jing, Hou Yiping Forensic Sci Int Genet IF: 3.6 2013-05-07

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