MIR150Gene Detail-Gene Database-Genelibs

MIR150 (microRNA 150)

symbol:: MIR150
locus group:: non-coding RNA
location:: 19q13.33
gene_family:: MicroRNAs
alias symbol:: hsa-mir-150
alias name:: None
entrez id:: 406942
ensembl gene id:: ENSG00000207782
ucsc gene id:: uc010yaw.2
refseq accession:: NR_029703
hgnc_id:: HGNC:31537
approved reserved:: 2004-04-23

19q13.33

ChineseEnglish

MIR150（microRNA-150）是一种小分子非编码RNA，属于microRNA基因家族，该家族成员通常通过结合靶基因的mRNA调控其翻译或稳定性，从而影响多种生物学过程。MIR150在造血系统、免疫调节和癌症发展中发挥重要作用，尤其在B细胞和T细胞的发育与功能中起关键作用。它通过抑制特定靶基因（如MYB、c-Myb）的表达来调控细胞分化、增殖和凋亡。MIR150的突变或表达异常可能导致其功能失调，例如在慢性淋巴细胞白血病（CLL）中，MIR150的表达水平通常降低，导致其靶基因c-Myb过度表达，进而促进癌细胞增殖。相反，MIR150的过表达可能抑制某些癌细胞的生长，如在急性髓系白血病（AML）中，高水平的MIR150可通过抑制致癌基因的表达发挥抑癌作用。此外，MIR150还参与心血管疾病和炎症反应的调控，例如在动脉粥样硬化中，MIR150通过调节血管内皮细胞功能影响疾病进展。MIR150属于高度保守的microRNA家族，该家族成员通常具有相似的生成机制（由Drosha和Dicer酶加工）和作用模式（通过RNA诱导沉默复合物RISC调控基因表达）。MIR150的表达水平受多种因素影响，包括表观遗传修饰和转录因子调控。其表达失调不仅影响自身功能，还可能通过调控下游信号通路（如PI3K/AKT、NF-κB）间接影响其他基因的表达或细胞功能。研究MIR150的调控机制和功能有助于开发新的疾病诊断标志物或治疗靶点，特别是在癌症和免疫相关疾病领域。

微RNA（miRNAs）是短（20-24核苷酸）非编码由既影响稳定性和mRNA的翻译参与基因表达的转录后调控在多细胞生物体的RNA。的miRNA通过RNA聚合酶II转录为加盖并聚腺苷酸化初级转录物的部分（PRI-微RNA），可以是任一蛋白质编码或非编码。初级转录由酶Drosha核糖核酸酶III酶裂解以产生约70个核苷酸茎 - 环前体miRNA（前miRNA），这是由胞质Dicer的核糖核酸酶进一步切割以产生成熟miRNA和反义miRNA的星（miRNA的* ）产品。成熟miRNA掺入RNA诱导的沉默复合物（RISC），其通过不完全碱基配对识别靶mRNA与所述miRNA和最通常导致翻译抑制或去稳定化的靶mRNA。所述的RefSeq表示预测的微RNA茎环。 [由RefSeq的，2009年09月提供]

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR150 Wikipedia entry for MIR150

Nucleotide sequence of MIR150:[NCBI]

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SNP variants of MIR150: Showing partial SNPs

rs2335157 rs2878354 rs2914670 rs2946844 rs13346708 rs13347116 rs35295508 rs41275778 rs61371437 rs73056059 rs73056062 rs77495679 rs79503050 rs79557008 rs79608257 rs112284181 rs113788509

Tissue expression of MIR150: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

No data available

Subcellular localization of MIR150 (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for MIR150:

microRNAs potentially regulating MIR150:

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Interacting Gene	Interaction	Source/Score

KEGG
Reactomepathway

Name
5206 MicroRNAs in cancer [PATH:hsa05206]

Name
Pre-NOTCH Expression and Processing
Pre-NOTCH Transcription and Translation
Signal Transduction
Signaling by NOTCH

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Fatty Liver	0.12	1	0	CTD_human
Neoplasm Metastasis	0.002714419	10	0	BeFree
Carcinogenesis	0.001628651	6	0	BeFree
Lymphoma	0.001357209	5	0	BeFree
Non-Small Cell Lung Carcinoma	0.001357209	5	0	BeFree
Chronic Lymphocytic Leukemia	0.001085767	4	0	BeFree
Malignant neoplasm of pancreas	0.001085767	4	0	BeFree
leukemia	0.001085767	4	0	BeFree
Pancreatic carcinoma	0.001085767	4	0	BeFree
Colorectal Carcinoma	0.001085767	4	0	BeFree

STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells.

Moles Ramona, Bellon Marcia, Nicot Christophe Neoplasia IF: 4.8 2016-02-18

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer.

Bertoli Gloria, Cava Claudia, Castiglioni Isabella Theranostics IF: 14.9 2016-04-25

Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth.

Hoareau-Aveilla Coralie, Valentin Thibaud, Daugrois Camille, Quelen Cathy, Mitou Géraldine, Quentin Samuel, Jia Jinsong, Spicuglia Salvatore, Ferrier Pierre, Ceccon Monica, Giuriato Sylvie, Gambacorti-Passerini Carlo, Brousset Pierre, Lamant Laurence, Meggetto Fabienne J Clin Invest IF: 14.3 2015-11-25

Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages.

Manoharan Palanikumar, Basford Joshua E, Pilcher-Roberts Robyn, Neumann Jonathan, Hui David Y, Lingrel Jerry B J Biol Chem IF: 4.1 2015-01-17

A functional screen identifies miRs that induce radioresistance in glioblastomas.

Moskwa Patryk, Zinn Pascal O, Choi Young Eun, Shukla Sachet A, Fendler Wojciech, Chen Clark C, Lu Jun, Golub Todd R, Hjelmeland Anita, Chowdhury Dipanjan Mol Cancer Res IF: 5.8 2015-08-14

Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker.

Punga Tanel, Le Panse Rozen, Andersson Mats, Truffault Frédérique, Berrih-Aknin Sonia, Punga Anna R Ann Clin Transl Neurol IF: 3.9 2014-10-30

[MicroRNA's role in sepsis and endotoxin tolerance. More players on the stage].

Gîză D E, Vasilescu C Chirurgia (Bucur) IF: 1.1 2011-01-03

Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression.

Barroga Charlene F, Pham Hang, Kaushansky Kenneth Exp Hematol IF: 2.7 2009-01-22

Short-term memory of danger signals or environmental stimuli in mesenchymal stem cells: implications for therapeutic potential.

Liu Guang-Yang, Liu Yang, Lu Ying, Qin Ya-Ru, Di Guo-Hu, Lei Yong-Hong, Liu Hu-Xian, Li Yan-Qi, Wu Chutse, Hu Xian-Wen, Duan Hai-Feng Cell Mol Immunol IF: 23.9 0000-00-00

Microvesicles enhance the mobility of human diabetic adipose tissue-derived mesenchymal stem cells in vitro and improve wound healing in vivo.

Trinh Nhu Thuy, Yamashita Toshiharu, Tu Tran Cam, Kato Toshiki, Ohneda Kinuko, Sato Fujio, Ohneda Osamu Biochem Biophys Res Commun IF: 2.5 0000-00-00

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MIR150 (microRNA 150)

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