MIR153-1 (microRNA 153-1)
- symbol:
- MIR153-1
- locus group:
- non-coding RNA
- location:
- 2q35
- gene_family:
- MicroRNAs
- alias symbol:
- hsa-mir-153-1
- alias name:
- None
- entrez id:
- 406944
- ensembl gene id:
- ENSG00000207647
- ucsc gene id:
- uc010zld.1
- refseq accession:
- NR_029688
- hgnc_id:
- HGNC:31539
- approved reserved:
- 2004-04-23
MicroRNAs (miRNAs) are short (20–24 nt) noncoding RNAs that post-transcriptionally regulate gene expression in multicellular organisms by affecting both mRNA stability and translation. They are transcribed by RNA polymerase II as parts of capped and polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. Pri-miRNAs are cleaved by Drosha ribonuclease III to produce approximately 70-nt stem-loop precursor miRNAs (pre-miRNAs), which are further processed by cytoplasmic Dicer into mature miRNAs and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing and most commonly causes translational inhibition or destabilization of the target mRNA. The RefSeq record represents the predicted microRNA stem-loop.
Gene Ontology
Subcellular localization of MIR153-1 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for MIR153-1:
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