MIR181B1 (microRNA 181b-1)
- symbol:
- MIR181B1
- locus group:
- non-coding RNA
- location:
- 1q32.1
- gene_family:
- MicroRNAs
- alias symbol:
- hsa-mir-181b-1
- alias name:
- None
- entrez id:
- 406955
- ensembl gene id:
- ENSG00000207975
- ucsc gene id:
- uc001gux.1
- refseq accession:
- NR_029612
- hgnc_id:
- HGNC:31550
- approved reserved:
- 2004-04-23
MIR181B1 encodes a microRNA (miRNA), a short (20–24 nt) noncoding RNA that post-transcriptionally regulates gene expression by affecting mRNA stability and translation in multicellular organisms. miRNAs are transcribed by RNA polymerase II as capped, polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. Pri-miRNAs are cleaved by the RNase III enzyme Drosha into ~70-nt stem-loop precursor miRNAs (pre-miRNAs), which are further processed by cytoplasmic Dicer to yield mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing and most often causes translational repression or destabilization of the target mRNA. RefSeq represents the predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]
Gene Ontology
Subcellular localization of MIR181B1 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for MIR181B1:
| Disease | Score | NofPmids | NofSnps | Source |
| Schizophrenia | 0.002367032 | 1 | 0 | GAD |
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