MIR19A (microRNA 19a)
- symbol:
- MIR19A
- locus group:
- non-coding RNA
- location:
- 13q31.3
- gene_family:
- MicroRNAs
- alias symbol:
- hsa-mir-19a
- alias name:
- None
- entrez id:
- 406979
- ensembl gene id:
- ENSG00000284204
- ucsc gene id:
- uc058xsv.1
- refseq accession:
- NR_029489
- hgnc_id:
- HGNC:31574
- approved reserved:
- 2004-04-23
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Gene Ontology
Subcellular localization of MIR19A (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for MIR19A:
| Disease | Score | NofPmids | NofSnps | Source |
| Neoplasm Metastasis | 0.121628651 | 7 | 0 | BeFree_CTD_human |
| Drug-Induced Liver Injury | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of ovary | 0.002638474 | 2 | 0 | BeFree_GAD |
| Stomach Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.001357209 | 5 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
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