MIR208A (microRNA 208a)

Gene Basic Information

Gene Basic Information

symbol:
MIR208A
locus group:
non-coding RNA
location:
14q11.2
gene_family:
MicroRNAs
alias symbol:
hsa-mir-208|hsa-mir-208a
alias name:
None
entrez id:
406990
ensembl gene id:
ENSG00000199157
ucsc gene id:
uc010tnn.3
refseq accession:
NR_029595
hgnc_id:
HGNC:31585
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

14q11.2

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR208A     Wikipedia entry for MIR208A

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR208A:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR208A:           Showing partial SNPs
rs451794       rs8022522       rs28730766       rs28730767       rs28730768       rs28730769       rs28730770       rs28730771       rs34935550       rs57660219       rs73604573       rs73604575       rs73604577       rs74039311       rs74039312       rs79877116       rs111638554      

Gene Expression

Gene Expression

Tissue expression of MIR208A:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR208A (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR208A:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR208A:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Carcinogenesis 0.000542884 2 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Acute myocardial infarction 0.000271442 1 0 BeFree
Malignant neoplasm of liver 0.000271442 1 0 BeFree
Liver and Intrahepatic Biliary Tract Carcinoma 0.000271442 1 0 BeFree
Cardiomyopathy, Dilated 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 0 BeFree

Related Publications

Related Publications

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Rare DCM associated variants in pre-miR-208a disrupt miRNA maturation and function.
Reckman YJ, Haas J, van der Made I, Williams SG, Diaz IG, Akhtar M, Mogensen J, Rasmussen TB, Villard E, Charron P, Elliott P, Keavney BD, Monserrat L, Pinto YM, Meder B, Tijsen AJ Hum Mol Genet IF: 3.1 2025-07-03
MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction.
Tony Hasahya, Meng Kai, Wu Bangwei, Yu Aijia, Zeng Qiutang, Yu Kunwu, Zhong Yucheng Mediators Inflamm IF: 4.9 2016-09-21
Trbp regulates heart function through microRNA-mediated Sox6 repression.
Ding Jian, Chen Jinghai, Wang Yanqun, Kataoka Masaharu, Ma Lixin, Zhou Pingzhu, Hu Xiaoyun, Lin Zhiqiang, Nie Mao, Deng Zhong-Liang, Pu William T, Wang Da-Zhi Nat Genet IF: 25.5 2015-09-09
cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes.
Fang Xiefan, Robinson Jourdon, Wang-Hu John, Jiang Lingli, Freeman Daniel A, Rivkees Scott A, Wendler Christopher C Am J Physiol Cell Physiol IF: 5.4 2015-12-04
Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes.
Fang Xiefan, Mei Wenbin, Barbazuk William B, Rivkees Scott A, Wendler Christopher C Am J Physiol Regul Integr Comp Physiol IF: 2.6 2015-02-11
Mechanical stretch via transforming growth factor-β1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes.
Wang Bao-Wei, Wu Gong-Jhe, Cheng Wen-Pin, Shyu Kou-Gi J Formos Med Assoc IF: 2.8 2014-06-09
Mechanical stretch via transforming growth factor-β1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts.
Shyu Kou-Gi, Wang Bao-Wei, Wu Gong-Jhe, Lin Chiu-Mei, Chang Hang Eur J Heart Fail IF: 10.3 2013-05-21

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