MIR214 (microRNA 214)

Gene Basic Information

Gene Basic Information

symbol:
MIR214
locus group:
non-coding RNA
location:
1q24.3
gene_family:
MicroRNAs
alias symbol:
hsa-mir-214
alias name:
None
entrez id:
406996
ensembl gene id:
ENSG00000283844
ucsc gene id:
uc021pev.3
refseq accession:
NR_029627
hgnc_id:
HGNC:31591
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

1q24.3

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR214     Wikipedia entry for MIR214

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR214:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR214:           Showing partial SNPs
rs57417995       rs73039374       rs74126008       rs74475928       rs75955082       rs77264026       rs115132259       rs115605846       rs117110263       rs139031456       rs139689939       rs142114300       rs142559836       rs142921282       rs143581704       rs143957259       rs147426735      

Gene Expression

Gene Expression

Tissue expression of MIR214:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTTGCTGTGCAGAACATCC
60
CTGGGTTGTCATGTGACTG
59
GTCTACACTTGCTGTGCAG
59
TCATGTGACTGCCTGTCTG
60
CTTGCTGTGCAGAACATCC
60
GTTGTCATGTGACTGCCTG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR214 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR214:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR214:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Mammary Neoplasms 0.120271442 2 0 BeFree_CTD_human
Neoplasm Metastasis 0.002714419 10 0 BeFree
Carcinogenesis 0.002171535 8 0 BeFree
Liver carcinoma 0.001900093 7 0 BeFree
Malignant neoplasm of ovary 0.001628651 6 0 BeFree
Ovarian Carcinoma 0.001628651 6 0 BeFree
Malignant neoplasm of breast 0.001085767 4 0 BeFree
melanoma 0.001085767 4 0 BeFree
Malignant tumor of cervix 0.001085767 4 0 BeFree
Cervix carcinoma 0.001085767 4 0 BeFree

Related Publications

Related Publications

Two further patients with the 1q24 deletion syndrome expand the phenotype: A possible role for the miR199-214 cluster in the skeletal features of the condition.
Ashraf Tazeen, Collinson Morag N, Fairhurst Joanna, Wang Rubin, Wilson Louise C, Foulds Nicola Am J Med Genet A IF: 1.7 2016-10-20
Refinement of genotype-phenotype correlation in 18 patients carrying a 1q24q25 deletion.
Chatron Nicolas, Haddad Véronique, Andrieux Joris, Désir Julie, Boute Odile, Dieux Anne, Baumann Clarisse, Drunat Séverine, Gérard Marion, Bonnet Céline, Leheup Bruno, Till Marianne, Rossi Massimiliano, Flori Elisabeth, Alembik Yves, Stewart Helen, McParland Joanna, Bernardini Laura, Castelluccio Pia, Roos Laura, Tümer Zeynep, Fagan Kerry, Hackett Anna, Bain Nicole, van Haeringen Arie, Ruivenkamp Claudia, Benzacken Brigitte, Sanlaville Damien, Edery Patrick, Aboura Azzedine, Schluth-Bolard Caroline Am J Med Genet A IF: 1.7 2016-01-08
miR214-regulated p53-NOX4/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells.
Ma Weijun, Li Jianping, Hu Juan, Cheng Ying, Wang Junli, Zhang Xiaotong, Xu Min Chem Biol Interact IF: 5.2 2016-05-26
A strategy for co-analysis of microRNAs and DNA.
Li Yan, Zhang Ji, Wei Wei, Wang Zheng, Prinz Mechthild, Hou Yiping Forensic Sci Int Genet IF: 3.6 2015-04-02
MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.
Polytarchou Christos, Hommes Daniel W, Palumbo Tiziana, Hatziapostolou Maria, Koutsioumpa Marina, Koukos Georgios, van der Meulen-de Jong Andrea E, Oikonomopoulos Angelos, van Deen Welmoed K, Vorvis Christina, Serebrennikova Oksana B, Birli Eleni, Choi Jennifer, Chang Lin, Anton Peter A, Tsichlis Philip N, Pothoulakis Charalabos, Verspaget Hein W, Iliopoulos Dimitrios Gastroenterology IF: 29.7 2015-12-29
Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.
Ip Blanche C, Liu Chun, Ausman Lynne M, von Lintig Johannes, Wang Xiang-Dong Cancer Prev Res (Phila) IF: 3.4 2015-07-30
Evolution of the miR199-214 cluster and vertebrate skeletal development.
Desvignes Thomas, Contreras Adam, Postlethwait John H RNA Biol IF: 4.1 2015-01-29
MicroRNAs in melanoma biology.
Kunz Manfred Adv Exp Med Biol IF: nan 2013-06-12
Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle.
Ahmed Farid E, Ahmed Nancy C, Vos Paul W, Bonnerup Chris, Atkins James N, Casey Michelle, Nuovo Gerard J, Naziri Wade, Wiley John E, Mota Helvecio, Allison Ron R Cancer Genomics Proteomics IF: 2.6 2013-12-30
Role of miRNAs in neuronal differentiation from human embryonic stem cell-derived neural stem cells.
Liu Jing, Githinji Jackline, Mclaughlin Bridget, Wilczek Kasia, Nolta Jan Stem Cell Rev IF: 2.967 2013-05-03

Related Services

Related Services

Comments

Comments

Loading comments...

Log in to post comments Log In Sign Up

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2