MIR215 (microRNA 215)

Gene Basic Information

Gene Basic Information

symbol:
MIR215
locus group:
non-coding RNA
location:
1q41
gene_family:
MicroRNAs
alias symbol:
hsa-mir-215
alias name:
None
entrez id:
406997
ensembl gene id:
ENSG00000207590
ucsc gene id:
uc010pui.2
refseq accession:
NR_029628
hgnc_id:
HGNC:31592
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

1q41

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR215     Wikipedia entry for MIR215

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR215:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR215:           Showing partial SNPs
rs2053251       rs2053252       rs3754060       rs3820455       rs72631834       rs74139285       rs74770127       rs75779112       rs78379784       rs78888417       rs112575662       rs113100691       rs113885162       rs114388084       rs115660502       rs137892351       rs139568926      

Gene Expression

Gene Expression

Tissue expression of MIR215:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CAGACAATATAGCTGAGTTTGTCTG
60
GTAGCACAGTCATACAGAATATTGG
60
GACAGACAATATAGCTGAGTTTGTC
60
CACAGTCATACAGAATATTGGCC
60
GACAATATAGCTGAGTTTGTCTGTC
60
GTAGCACAGTCATACAGAATATTGG
60

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR215 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR215:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR215:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Liver Cirrhosis 0.12 1 0 CTD_human
Colorectal Cancer 0.000814326 3 0 BeFree
Colorectal Carcinoma 0.000814326 3 0 BeFree
Malignant tumor of colon 0.000542884 2 0 BeFree
Colon Carcinoma 0.000542884 2 0 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Renal Cell Carcinoma 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Metastatic Renal Cell Cancer 0.000271442 1 0 BeFree

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