MIR217 (microRNA 217)

Gene Basic Information

Gene Basic Information

symbol:
MIR217
locus group:
non-coding RNA
location:
2p16.1
gene_family:
MicroRNAs
alias symbol:
hsa-mir-217|miR-217
alias name:
None
entrez id:
406999
ensembl gene id:
ENSG00000207548
ucsc gene id:
uc010ypd.2
refseq accession:
NR_029630
hgnc_id:
HGNC:31594
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

2p16.1

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR217     Wikipedia entry for MIR217

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR217:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR217:           Showing partial SNPs
rs6745615       rs6756818       rs10204798       rs11303332       rs13398053       rs13432828       rs34380800       rs41291173       rs41291175       rs41291177       rs71416150       rs72813868       rs74996383       rs79617475       rs111274244       rs111712148       rs111857538      

Gene Expression

Gene Expression

Tissue expression of MIR217:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TGCATCAGGAACTGATTGGA
60
CTGAAGGCAATGCATTAGGA
58
TGCATCAGGAACTGATTGG
58
CTGAAGGCAATGCATTAGGA
58
CTGCATCAGGAACTGATTGG
59
TGAAGGCAATGCATTAGGA
57

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR217 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR217:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR217:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Squamous cell carcinoma of esophagus 0.120271442 1 0 BeFree_CTD_human
Neoplasm Invasiveness 0.12 1 0 CTD_human
Drug-Induced Liver Injury 0.12 1 0 CTD_human
Pancreatic Ductal Adenocarcinoma 0.001085767 4 0 BeFree
Carcinogenesis 0.000814326 3 0 BeFree
Neoplasm Metastasis 0.000814326 3 0 BeFree
Osteosarcoma 0.000542884 2 0 BeFree
Osteosarcoma of bone 0.000542884 2 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree

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Related Publications

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