MIR218-2 (microRNA 218-2)

Gene Basic Information

Gene Basic Information

symbol:
MIR218-2
locus group:
non-coding RNA
location:
5q34
gene_family:
MicroRNAs
alias symbol:
hsa-mir-218-2
alias name:
None
entrez id:
407001
ensembl gene id:
ENSG00000207739
ucsc gene id:
uc010jjh.3
refseq accession:
NR_029632
hgnc_id:
HGNC:31596
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

5q34

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR218-2     Wikipedia entry for MIR218-2

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR218-2:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR218-2:           Showing partial SNPs
rs1368355       rs6877341       rs6877545       rs9784690       rs9784693       rs10155543       rs11134527       rs11424849       rs11746483       rs17553555       rs41275327       rs67107739       rs73802395       rs74706972       rs75267934       rs75915349       rs77471673      

Gene Expression

Gene Expression

Tissue expression of MIR218-2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTCCTTTGTGCTTGATCTAACC
59
TTGACAGAACCATGTTCCG
58
TCCTTTGTGCTTGATCTAACC
58
CTTGACAGAACCATGTTCCG
59
CCTTTGTGCTTGATCTAACCA
59
GCTTGACAGAACCATGTTCC
60

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR218-2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR218-2:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR218-2:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Multiple malignancy 0.000271442 1 0 BeFree
Malignant neoplasm of thyroid 0.000271442 1 0 BeFree
Thyroid carcinoma 0.000271442 1 0 BeFree

Related Publications

Related Publications

Motor neuron-expressed microRNAs 218 and their enhancers are nested within introns of Slit2/3 genes.
Punnamoottil Beena, Rinkwitz Silke, Giacomotto Jean, Svahn Adam J, Becker Thomas S Genesis IF: 2.8 2016-02-09
miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner.
Shi Ying, Chen Guo-Bin, Huang Qing-Wen, Chen Xu, Liu Jing-Jing, Xu Wei, Huang Xiao-Xiao, Liu Yun-Peng, Xiao Chuan-Xing, Wu Deng-Chyang, Guleng Bayasi, Ren Jian-Lin Biochim Biophys Acta 2015-10-01

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