MIR224 (microRNA 224)

Gene Basic Information

Gene Basic Information

symbol:
MIR224
locus group:
non-coding RNA
location:
Xq28
gene_family:
MicroRNAs
alias symbol:
hsa-mir-224
alias name:
None
entrez id:
407009
ensembl gene id:
ENSG00000284363
ucsc gene id:
uc033fab.1
refseq accession:
NR_029638
hgnc_id:
HGNC:31604
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

Xq28

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR224     Wikipedia entry for MIR224

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR224:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR224:           Showing partial SNPs
rs781374253       rs781141889       rs781092437       rs781088784       rs780597446       rs780264556       rs779547865       rs778971784       rs778678135       rs778248330       rs777628366       rs776755833       rs776702509       rs776429138       rs776411145       rs775496761       rs773464738      

Gene Expression

Gene Expression

Tissue expression of MIR224:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CAAGTCACTAGTGGTTCCG
57
TTGTAGTCACTAGGGCACC
58
AAGTCACTAGTGGTTCCGT
58
TTGTAGTCACTAGGGCACC
58
GGTTCCGTTTAGTAGATGATTGTG
59
GGGCTTTGTAGTCACTAGGG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR224 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR224:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR224:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Neoplasm Metastasis 0.121900093 8 0 BeFree_CTD_human
Liver carcinoma 0.002714419 10 0 BeFree
Colorectal Cancer 0.001900093 7 0 BeFree
Prostate carcinoma 0.001900093 7 0 BeFree
Carcinogenesis 0.001900093 7 0 BeFree
Malignant neoplasm of prostate 0.001900093 7 0 BeFree
Colorectal Carcinoma 0.001628651 6 0 BeFree
Tumor Progression 0.001085767 4 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Thyroid Neoplasm 0.000542884 2 0 BeFree

Related Publications

Related Publications

MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.
Guo Xing, Xue Hao, Guo Xiaofan, Gao Xiao, Xu Shugang, Yan Shaofeng, Han Xiao, Li Tong, Shen Jie, Li Gang Oncotarget IF: 5.168 2016-09-26
Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis.
Lan Sheng-Hui, Wu Shan-Ying, Zuchini Roberto, Lin Xi-Zhang, Su Ih-Jen, Tsai Ting-Fen, Lin Yen-Ju, Wu Cheng-Tao, Liu Hsiao-Sheng Autophagy IF: 18.6 2015-07-21
Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.
Ostenfeld Marie Stampe, Jeppesen Dennis K, Laurberg Jens R, Boysen Anders T, Bramsen Jesper B, Primdal-Bengtson Bjarke, Hendrix An, Lamy Philippe, Dagnaes-Hansen Frederik, Rasmussen Mads H, Bui Khan H, Fristrup Niels, Christensen Erik I, Nordentoft Iver, Morth Jens P, Jensen Jørgen B, Pedersen Jakob S, Beck Martin, Theodorescu Dan, Borre Michael, Howard Kenneth A, Dyrskjøt Lars, Ørntoft Torben Falck Cancer Res IF: 22.6 2014-12-22
[Predictive and prognostic factors of gastric cancer].
Šmíd D, Kubačková D, Doležal J, Fichtl J, Pešta M, Kulda V, Daum O, Třeška V, Skalický T Rozhl Chir 0000-00-00

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