MIR26A1 (microRNA 26a-1)
- symbol:
- MIR26A1
- locus group:
- non-coding RNA
- location:
- 3p22.2
- gene_family:
- MicroRNAs
- alias symbol:
- hsa-mir-26a-1
- alias name:
- None
- entrez id:
- 407015
- ensembl gene id:
- ENSG00000199075
- ucsc gene id:
- uc011ayg.2
- refseq accession:
- NR_029499
- hgnc_id:
- HGNC:31610
- approved reserved:
- 2004-04-23
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Gene Ontology
Subcellular localization of MIR26A1 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for MIR26A1:
| Name |
|---|
| 5206 MicroRNAs in cancer [PATH:hsa05206] |
| Name |
|---|
| Adaptive Immune System |
| DAP12 interactions |
| DAP12 signaling |
| Downstream signal transduction |
| Downstream signaling events of B Cell Receptor (BCR) |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| Fc epsilon receptor (FCERI) signaling |
| GAB1 signalosome |
| Immune System |
| Innate Immune System |
| NGF signalling via TRKA from the plasma membrane |
| PI-3K cascade:FGFR1 |
| PI-3K cascade:FGFR2 |
| PI-3K cascade:FGFR3 |
| PI-3K cascade:FGFR4 |
| PI3K events in ERBB2 signaling |
| PI3K events in ERBB4 signaling |
| PI3K/AKT activation |
| PIP3 activates AKT signaling |
| Role of LAT2/NTAL/LAB on calcium mobilization |
| Signal Transduction |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by PDGF |
| Signaling by SCF-KIT |
| Signaling by the B Cell Receptor (BCR) |
| Signalling by NGF |
| Disease | Score | NofPmids | NofSnps | Source |
| Arthritis, Experimental | 0.08 | 1 | 0 | CTD_rat |
| Liver Neoplasms, Experimental | 0.08 | 1 | 0 | CTD_rat |
| Kidney Neoplasm | 0.002367032 | 1 | 0 | GAD |
| Renal Cell Carcinoma | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of esophagus | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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