MIR296 (microRNA 296)

Gene Basic Information

Gene Basic Information

symbol:
MIR296
locus group:
non-coding RNA
location:
20q13.32
gene_family:
MicroRNAs
alias symbol:
hsa-mir-296
alias name:
None
entrez id:
407022
ensembl gene id:
ENSG00000284040
ucsc gene id:
uc002xzr.1
refseq accession:
NR_029844
hgnc_id:
HGNC:31617
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

20q13.32

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR296     Wikipedia entry for MIR296

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR296:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR296:           Showing partial SNPs
rs3746709       rs6015381       rs6026543       rs6026544       rs6070625       rs34756977       rs73129515       rs75650358       rs77501163       rs78572212       rs111431585       rs112033207       rs143922736       rs146836437       rs180962558       rs374132667       rs531273498      

Gene Expression

Gene Expression

Tissue expression of MIR296:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR296 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR296:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR296:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Myocardial Reperfusion Injury 0.12 1 0 CTD_human
Esophageal carcinoma 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Adenoma 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree

Related Publications

Related Publications

DNA methylation analysis with nasal brushing for early diagnosis of sinonasal malignant tumours.
Morandi L, Farneti P, Leucci AC, Querzoli G, Melotti S, Camagni A, Galli P, Sollini G, Franchi A, Tonon C, Lodi R, Pasquini E, Foschini MP Discov Oncol 2026-01-29
Schizophrenia-Associated MIR204 Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Channel Gene Sets.
Cammaerts Sophia, Strazisar Mojca, Smets Bart, Weckhuysen Sarah, Nordin Annelie, De Jonghe Peter, Adolfsson Rolf, De Rijk Peter, Del Favero Jurgen PLoS One IF: 2.6 2016-06-29
miRNA-296-3p modulates chemosensitivity of lung cancer cells by targeting CX3CR1.
Luo Wen, Lin Yuanlong, Meng Shanshan, Guo Yuening, Zhang Jiawen, Zhang Wei Am J Transl Res 2016-05-17
Imprinting genes associated with endometriosis.
Kobayashi Hiroshi EXCLI J IF: 6.2 2015-09-29
miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer.
Nordentoft Iver, Birkenkamp-Demtroder Karin, Agerbæk Mads, Theodorescu Dan, Ostenfeld Marie Stampe, Hartmann Arndt, Borre Michael, Ørntoft Torben F, Dyrskjøt Lars BMC Med Genomics IF: 2.848 2013-03-05

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