MIR323B (microRNA 323b)

symbol:
MIR323B
locus group:
non-coding RNA
location:
14q32.31
gene_family:
MicroRNAs
alias symbol:
hsa-mir-323b|hsa-mir-453
alias name:
None
entrez id:
574410
ensembl gene id:
ENSG00000208004
ucsc gene id:
uc021sdn.1
refseq accession:
NR_029969
hgnc_id:
HGNC:38349
approved reserved:
2010-04-30
14q32.31
ChineseEnglish

MicroRNAs (miRNAs) are short (20–24 nt) noncoding RNAs that regulate gene expression post-transcriptionally in multicellular organisms by affecting mRNA stability and translation. miRNAs are transcribed by RNA polymerase II as parts of capped and polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by cytoplasmic Dicer to yield mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. This RefSeq represents the predicted microRNA stem-loop for MIR323B. [Provided by RefSeq, Sep 2009]

Nucleotide sequence of MIR323B:[NCBI]
Loading Gene Browser...
SNP variants of MIR323B:           Showing partial SNPs
rs28611020       rs77282763       rs78832380       rs114049845       rs115002548       rs118127537       rs143266241       rs148248549       rs149164553       rs185129704       rs192719529       rs200200058       rs201521235       rs202017986       rs368481071       rs369244268       rs369674733      

Tissue expression of MIR323B:    [UniProt]

Gene expression across tissues
Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
      No data available

Subcellular localization of MIR323B (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR323B:

microRNAs potentially regulating MIR323B:     

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Interacting Gene Interaction Source/Score
Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of breast 0.000542884 2 1 BeFree
Breast Carcinoma 0.000542884 2 1 BeFree
Hepatitis B 0.000271442 1 0 BeFree
Virus Diseases 0.000271442 1 0 BeFree

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