MIR34AHG (MIR34A host gene)

Gene Basic Information

Gene Basic Information

symbol:
MIR34AHG
locus group:
non-coding RNA
location:
1p36.22
gene_family:
None
alias symbol:
None
alias name:
None
entrez id:
106614088
ensembl gene id:
ENSG00000228526
ucsc gene id:
None
refseq accession:
NR_132742
hgnc_id:
HGNC:51913
approved reserved:
2015-10-01

Chromosome Location

Chromosome Location

1p36.22

Gene Summary

Gene Summary

MIR34AHG（MicroRNA 34a Host Gene）是一个长链非编码RNA（lncRNA）基因，位于人类染色体1p36.22区域。它作为miR-34a的前体基因，通过转录生成miR-34a，这是一种重要的肿瘤抑制性microRNA。MIR34AHG及其产物miR-34a在多种生物学过程中发挥关键作用，包括细胞周期调控、凋亡诱导、衰老和DNA损伤修复。miR-34a通过靶向多个癌基因（如MYC、MET、CDK4/6和BCL2）来抑制肿瘤生长，因此在多种癌症（如乳腺癌、肺癌和结直肠癌）中常发现MIR34AHG/miR-34a的表达下调或缺失。MIR34AHG的突变或表观遗传沉默可能导致miR-34a表达降低，从而削弱其肿瘤抑制功能，促进癌症进展。此外，MIR34AHG还参与神经退行性疾病和心血管疾病的调控。当MIR34AHG过表达时，可通过增加miR-34a水平抑制肿瘤细胞增殖并诱导凋亡；而降低表达则可能促进细胞恶性转化。MIR34AHG属于MIR34家族，该家族还包括MIR34B和MIR34C，它们共享相似的肿瘤抑制功能并通过调控重叠的靶基因网络参与癌症抑制。MIR34家族成员在多种组织中表达，并在应激反应、代谢调控和免疫调节中发挥重要作用。由于其在疾病中的关键作用，MIR34AHG/miR-34a已成为癌症治疗和诊断的潜在靶点。

OMIM entry for MIR34AHG     Wikipedia entry for MIR34AHG

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR34AHG:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR34AHG:           Showing partial SNPs
rs797257       rs797264       rs797265       rs6657463       rs6669897       rs6688037       rs6688039       rs10779709       rs11584857       rs12141050       rs57146980       rs61787668       rs70985602       rs74051117       rs76459758       rs76858440       rs79041007      

Gene Expression

Gene Expression

Tissue expression of MIR34AHG:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR34AHG (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR34AHG:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR34AHG:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

Related Services

Related Services

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