MicroRNAs (miRNAs) are short (20–24 nucleotide) noncoding RNAs that participate in post-transcriptional regulation of gene expression in multicellular organisms by affecting both mRNA stability and translation. miRNAs are transcribed by RNA polymerase II as parts of capped and polyadenylated primary transcripts (pri-miRNAs), which may be either protein-coding or noncoding. The primary transcript is cleaved by the ribonuclease III enzyme Drosha to produce an approximately 70-nucleotide stem-loop precursor miRNA (pre-miRNA), which is further cleaved by cytoplasmic Dicer ribonuclease to yield mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq representation predicts a microRNA stem-loop. [Provided by RefSeq, Sep 2009]
Subcellular localization of MIR3661 (and its protein):
Gene Ontology (GO) terms for MIR3661:
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