MIR373 (microRNA 373)

Gene Basic Information

Gene Basic Information

symbol:
MIR373
locus group:
non-coding RNA
location:
19q13.42
gene_family:
MicroRNAs
alias symbol:
hsa-mir-373
alias name:
None
entrez id:
442918
ensembl gene id:
ENSG00000199143
ucsc gene id:
uc010yee.1
refseq accession:
NR_029866
hgnc_id:
HGNC:31787
approved reserved:
2004-07-22

Chromosome Location

Chromosome Location

19q13.42

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR373     Wikipedia entry for MIR373

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR373:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR373:           Showing partial SNPs
rs3859501       rs11084296       rs11084297       rs11880440       rs12460972       rs12983508       rs28461391       rs28465387       rs35432554       rs41275806       rs67124692       rs74180590       rs76038528       rs76335922       rs77563076       rs78762607       rs79365487      

Gene Expression

Gene Expression

Tissue expression of MIR373:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR373 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR373:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR373:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of esophagus 0.002638474 2 0 BeFree_GAD
Kidney Neoplasm 0.002367032 1 0 GAD
Neoplasm Recurrence, Local 0.002367032 1 0 GAD
Renal Cell Carcinoma 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.001900093 7 4 BeFree
Breast Carcinoma 0.001628651 6 4 BeFree
Carcinogenesis 0.001628651 6 0 BeFree
Neoplasm Metastasis 0.001085767 4 0 BeFree
Klatskin Tumor 0.000814326 3 0 BeFree
Germ cell tumor 0.000814326 3 0 BeFree

Related Publications

Related Publications

MicroRNAs and metastasis-related gene expression in Egyptian breast cancer patients.
Hafez Mohamed M, Hassan Zeinab K, Zekri Abdel Rahman N, Gaber Ayman A, Al Rejaie Salem S, Sayed-Ahmed Mohamed M, Al Shabanah Othman Asian Pac J Cancer Prev IF: 0.000 2012-09-20

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