MIR4436B1 (microRNA 4436b-1)

Gene Basic Information

Gene Basic Information

symbol:
MIR4436B1
locus group:
non-coding RNA
location:
2q13
gene_family:
MicroRNAs
alias symbol:
hsa-mir-4436b
alias name:
None
entrez id:
100616123
ensembl gene id:
ENSG00000264979
ucsc gene id:
uc031ror.1
refseq accession:
NR_039941
hgnc_id:
HGNC:41587
approved reserved:
2011-05-02

Chromosome Location

Chromosome Location

2q13

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR4436B1     Wikipedia entry for MIR4436B1

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR4436B1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR4436B1:           Showing partial SNPs
rs163641       rs163642       rs163643       rs3843849       rs3976233       rs7564474       rs55680625       rs59754519       rs111414768       rs111833530       rs112876731       rs112914972       rs113678971       rs200474510       rs201976208      

Gene Expression

Gene Expression

Tissue expression of MIR4436B1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTCACTTGTCCACTTCTGC
59
ACTTGTCCACTTCTTCCTG
57
CCTCACTTGTCCACTTCTG
58
CTTGTCCACTTCTTCCTGC
59
CTCACTTGTCCACTTCTGC
59
CTTGTCCACTTCTTCCTGC
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR4436B1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR4436B1:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR4436B1:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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