MIR4452 (microRNA 4452)

Gene Basic Information

Gene Basic Information

symbol:
MIR4452
locus group:
non-coding RNA
location:
4q21.3
gene_family:
MicroRNAs
alias symbol:
hsa-mir-4452
alias name:
None
entrez id:
100616463
ensembl gene id:
ENSG00000266515
ucsc gene id:
uc032toy.1
refseq accession:
NR_039657
hgnc_id:
HGNC:41539
approved reserved:
2011-05-02

Chromosome Location

Chromosome Location

4q21.3

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR4452     Wikipedia entry for MIR4452

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR4452:[NCBI]
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Gene Variants

Gene Variants

SNP variants of MIR4452:           Showing partial SNPs
rs4529013       rs7665384       rs11733860       rs72665744       rs76480086       rs79435185       rs111462603       rs113368122       rs115430586       rs116060894       rs116170019       rs117719306       rs137982781       rs140597058       rs140658564       rs142259265       rs144428845      

Gene Expression

Gene Expression

Tissue expression of MIR4452:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GATCACTTGAGGCCAAGAG
58
CTTAAGGCCAAGAATTCAAGG
57
TCACTTGAGGCCAAGAGTG
60
ACTTAAGGCCAAGAATTCAAGG
59
GATCACTTGAGGCCAAGAG
58
TTAAGGCCAAGAATTCAAGGC
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR4452 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR4452:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR4452:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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