MIR4457 (microRNA 4457)

Gene Basic Information

Gene Basic Information

symbol:
MIR4457
locus group:
non-coding RNA
location:
5p15.33
gene_family:
MicroRNAs
alias symbol:
hsa-mir-4457
alias name:
None
entrez id:
100616235
ensembl gene id:
ENSG00000263670
ucsc gene id:
uc021xwd.1
refseq accession:
NR_039662
hgnc_id:
HGNC:41554
approved reserved:
2011-05-02

Chromosome Location

Chromosome Location

5p15.33

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR4457     Wikipedia entry for MIR4457

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR4457:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR4457:           Showing partial SNPs
rs6554758       rs12332579       rs34947319       rs56335551       rs60622800       rs61574973       rs72709472       rs74608764       rs75487766       rs76597939       rs114160066       rs114582554       rs114698255       rs115123234       rs115769169       rs116674472       rs116919101      

Gene Expression

Gene Expression

Tissue expression of MIR4457:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TCCAGTCAATACCGTGTGAG
60
TGAATACGCCAGTCAATACCT
59
TCCAGTCAATACCGTGTGAG
60
TGAATACGCCAGTCAATACC
58
CTCCAGTCAATACCGTGTG
58
GAATACGCCAGTCAATACCT
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR4457 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR4457:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR4457:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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