MIR4473 (microRNA 4473)

Gene Basic Information

Gene Basic Information

symbol:
MIR4473
locus group:
non-coding RNA
location:
9p21.3
gene_family:
MicroRNAs
alias symbol:
hsa-mir-4473
alias name:
None
entrez id:
100616229
ensembl gene id:
ENSG00000263790
ucsc gene id:
uc022bdy.1
refseq accession:
NR_039684
hgnc_id:
HGNC:41540
approved reserved:
2011-05-02

Chromosome Location

Chromosome Location

9p21.3

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR4473     Wikipedia entry for MIR4473

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR4473:[NCBI]
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Gene Variants

Gene Variants

SNP variants of MIR4473:           Showing partial SNPs
rs1334363       rs1360729       rs4382555       rs10964555       rs16938058       rs16938059       rs16938060       rs73648211       rs75532859       rs75798356       rs78616695       rs78743257       rs78909008       rs80109557       rs113951133       rs117054042       rs140278320      

Gene Expression

Gene Expression

Tissue expression of MIR4473:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ATGGAGAACACTAAGCTATGG
57
GGGATACTTGTAACGGAGAG
57
GTAATGGAGAACACTAAGCTATGG
59
ATACTTGTAACGGAGAGCAC
57
GACACTTGTAATGGAGAACAC
57
TAACGGAGAGCACTAGCAG
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR4473 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR4473:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR4473:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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