MIR618 (microRNA 618)

Gene Basic Information

Gene Basic Information

symbol:
MIR618
locus group:
non-coding RNA
location:
12q21.31
gene_family:
MicroRNAs
alias symbol:
hsa-mir-618
alias name:
None
entrez id:
693203
ensembl gene id:
ENSG00000208022
ucsc gene id:
uc021rbc.1
refseq accession:
NR_030349
hgnc_id:
HGNC:32874
approved reserved:
2006-05-17

Chromosome Location

Chromosome Location

12q21.31

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR618     Wikipedia entry for MIR618

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR618:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR618:           Showing partial SNPs
rs1716543       rs2682818       rs11387348       rs11613504       rs11614433       rs17732904       rs73345662       rs74342046       rs111921327       rs112896026       rs114099308       rs114953945       rs140796492       rs143114479       rs144034647       rs145551269       rs146436490      

Gene Expression

Gene Expression

Tissue expression of MIR618:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTTGTCCTTCTGAGTGTAATTACG
60
AGGGTAAACCTGCTTGTCTC
60
AGCCAAACTCTACTTGTCCT
59
CTTGTCTCCTGAGCTACTG
57
AGCCAAACTCTACTTGTCC
57
CTTGTCTCCTGAGCTACTG
57

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR618 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR618:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR618:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Uterine Corpus Cancer 0.000271442 1 0 BeFree
Malignant neoplasm of endometrium 0.000271442 1 0 BeFree
Anaplastic thyroid carcinoma 0.000271442 1 0 BeFree
Endometrial Carcinoma 0.000271442 1 0 BeFree

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