MIR628 (microRNA 628)

Gene Basic Information

Gene Basic Information

symbol:
MIR628
locus group:
non-coding RNA
location:
15q21.3
gene_family:
MicroRNAs
alias symbol:
hsa-mir-628
alias name:
None
entrez id:
693213
ensembl gene id:
ENSG00000283891
ucsc gene id:
uc021smv.2
refseq accession:
NR_030358
hgnc_id:
HGNC:32884
approved reserved:
2006-05-17

Chromosome Location

Chromosome Location

15q21.3

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR628     Wikipedia entry for MIR628

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR628:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR628:           Showing partial SNPs
rs8041044       rs8041885       rs10518810       rs57576913       rs58550265       rs72742301       rs78286079       rs79587787       rs111722450       rs112498125       rs112813593       rs113216902       rs115010895       rs139314683       rs141933238       rs143702654       rs148125543      

Gene Expression

Gene Expression

Tissue expression of MIR628:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GTCACTTCCTCATGCTGAC
58
CTGCCACTCTTACTAGAAGGT
59
GTCACTTCCTCATGCTGAC
58
CTGCCACTCTTACTAGAAGG
57
GTCACTTCCTCATGCTGAC
58
TGCCACTCTTACTAGAAGGT
57

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR628 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR628:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR628:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree

Related Publications

Related Publications

MicroRNA 628-5p as a novel biomarker for cardiac allograft vasculopathy.
Neumann A, Napp L C, Kleeberger J A, Benecke N, Pfanne A, Haverich A, Thum T, Bara C Transplantation IF: 4.9 0000-00-00

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