MicroRNAs (miRNAs) are short, 20–24 nucleotide noncoding RNAs that post-transcriptionally regulate gene expression in multicellular organisms by influencing mRNA stability and translation. miRNA genes are transcribed by RNA polymerase II into capped and polyadenylated primary transcripts (pri-miRNAs), which can be protein-coding or noncoding. The primary transcript is cleaved by the nuclear RNase III enzyme Drosha to produce an approximately 70-nucleotide stem-loop precursor miRNA (pre-miRNA), which cytoplasmic Dicer further cleaves to release mature miRNA and antisense miRNA star (miRNA*) products. Mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing and usually leads to translational repression or destabilization of the target mRNA. The RefSeq entry for MIR6716 represents a predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]
Subcellular localization of MIR6716 (and its protein):
Gene Ontology (GO) terms for MIR6716:
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