MicroRNAs (miRNAs) are short (20–24 nt) noncoding RNAs that post-transcriptionally regulate gene expression in multicellular organisms by affecting both mRNA stability and translation. miRNA genes are transcribed by RNA polymerase II as parts of capped and polyadenylated primary transcripts (pri-miRNAs), which may be either protein-coding or noncoding. Pri-miRNAs are cleaved by the Drosha ribonuclease III enzyme to produce approximately 70-nt stem-loop precursor miRNAs (pre-miRNAs), which are further cleaved by cytoplasmic Dicer to generate mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing and most commonly results in translational inhibition or destabilization of the target mRNA. RefSeq represents MIR7158 as a predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]
Subcellular localization of MIR7158 (and its protein):
Gene Ontology (GO) terms for MIR7158:
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