MicroRNAs (miRNAs) are short (20–24 nucleotide) non-coding RNAs that post-transcriptionally regulate gene expression in multicellular organisms by affecting mRNA stability and translation. miRNAs are transcribed by RNA polymerase II as capped and polyadenylated primary transcripts (pri-miRNAs), which can be either protein-coding or non-coding. Pri-miRNAs are cleaved by the RNase III enzyme Drosha to produce approximately 70-nucleotide stem-loop precursor miRNAs (pre-miRNAs), which are further cleaved by cytoplasmic Dicer to generate mature miRNA and antisense miRNA star (miRNA*) products. Mature miRNAs are incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly leads to translational repression or destabilization of the target mRNA. The RefSeq record represents a predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]
Subcellular localization of MIR8082 (and its protein):
Gene Ontology (GO) terms for MIR8082:
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