MIR9-2 (microRNA 9-2)

Gene Basic Information

Gene Basic Information

symbol:
MIR9-2
locus group:
non-coding RNA
location:
5q14.3
gene_family:
MicroRNAs
alias symbol:
hsa-mir-9-2
alias name:
None
entrez id:
407047
ensembl gene id:
ENSG00000284447
ucsc gene id:
uc021ybf.1
refseq accession:
NR_030741
hgnc_id:
HGNC:31642
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

5q14.3

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR9-2     Wikipedia entry for MIR9-2

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR9-2:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR9-2:           Showing partial SNPs
rs1501672       rs1501673       rs2304608       rs5869431       rs13162910       rs13174905       rs41265488       rs77516652       rs111952236       rs113794889       rs116208545       rs116419961       rs140357203       rs144321978       rs147152591       rs147719390       rs147816379      

Gene Expression

Gene Expression

Tissue expression of MIR9-2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAAGCGAGTTGTTATCTTTGGT
59
CGGTTATCTAGCTTTATGAAGACC
59
GAAGCGAGTTGTTATCTTTGG
57
CGGTTATCTAGCTTTATGAAGACC
59
AGCGAGTTGTTATCTTTGGT
57
CGGTTATCTAGCTTTATGAAGACC
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR9-2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR9-2:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR9-2:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of ovary 0.002367032 1 0 GAD
Chronic Lymphocytic Leukemia 0.000271442 1 0 BeFree
Multiple Myeloma 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree

Related Publications

Related Publications

Investigation of miR9-1, miR9-2 and miR9-3 Methylation in Hodgkin Lymphoma.
Ben Dhiab Myriam, Ziadi Sonia, Louhichi Teheni, Ben Gacem Riadh, Ksiaa Feryel, Trimeche Mounir Pathobiology IF: 1.7 2016-07-11
Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants.
Hauberg Mads Engel, Roussos Panos, Grove Jakob, Børglum Anders Dupont, Mattheisen Manuel, JAMA Psychiatry IF: 18.0 2016-08-22
Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family.
Rodriguez-Otero Paula, Román-Gómez José, Vilas-Zornoza Amaia, José-Eneriz Edurne San, Martín-Palanco Vanesa, Rifón José, Torres Antonio, Calasanz María José, Agirre Xabier, Prosper Felipe Br J Haematol IF: 3.6 2014-05-09

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