MIR98 (microRNA 98)

Gene Basic Information

Gene Basic Information

symbol:
MIR98
locus group:
non-coding RNA
location:
Xp11.22
gene_family:
MicroRNAs
alias symbol:
hsa-mir-98|MIRLET7L
alias name:
microRNA let-7l
entrez id:
407054
ensembl gene id:
ENSG00000271886
ucsc gene id:
uc004dsr.2
refseq accession:
NR_029513
hgnc_id:
HGNC:31649
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

Xp11.22

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIR98     Wikipedia entry for MIR98

Gene Sequence

Gene Sequence

Nucleotide sequence of MIR98:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIR98:           Showing partial SNPs
rs782819170       rs782810510       rs782760005       rs782751944       rs782749027       rs782719709       rs782705832       rs782683116       rs782652107       rs782643468       rs782601799       rs782577397       rs782567016       rs782531751       rs782524177       rs782515496       rs782509375      

Gene Expression

Gene Expression

Tissue expression of MIR98:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGGATTCTGCTCATGCCAG
60
GGGCCTAATATCCCTACCC
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIR98 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIR98:

Related microRNA

Related microRNA

microRNAs potentially regulating MIR98:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Liver Neoplasms, Experimental 0.12 1 0 CTD_human
Precancerous Conditions 0.12 1 0 CTD_human
Neoplasm Metastasis 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Lupus Erythematosus, Systemic 0.000271442 1 0 BeFree
Malignant neoplasm of endometrium 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Lupus Erythematosus 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Endometrial Carcinoma 0.000271442 1 0 BeFree

Related Publications

Related Publications

CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis.
Lin Xiaorong, Chen Lijun, Yao Yandang, Zhao Ruihua, Cui Xiuying, Chen Jun, Hou Kailian, Zhang Mingxia, Su Fengxi, Chen Jingqi, Song Erwei Oncotarget IF: 5.168 2016-07-13
Coordinate regulation of microenvironmental stimuli and role of methylation in bone metastasis from breast carcinoma.
Matteucci Emanuela, Maroni Paola, Disanza Andrea, Bendinelli Paola, Desiderio Maria Alfonsina Biochim Biophys Acta 2016-04-26
Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation.
Kawahara Hironori, Okada Yohei, Imai Takao, Iwanami Akio, Mischel Paul S, Okano Hideyuki J Biol Chem IF: 4.1 2011-07-01

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