MIRLET7A2 (microRNA let-7a-2)

Gene Basic Information

Gene Basic Information

symbol:
MIRLET7A2
locus group:
non-coding RNA
location:
11q24.1
gene_family:
MicroRNAs
alias symbol:
hsa-let-7a-2
alias name:
None
entrez id:
406882
ensembl gene id:
ENSG00000198975
ucsc gene id:
uc001pyg.4
refseq accession:
NR_029477
hgnc_id:
HGNC:31477
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

11q24.1

Gene Summary

Gene Summary

ChineseEnglish

MIRLET7A2 is represented in RefSeq as a predicted microRNA stem-loop. MicroRNAs (miRNAs) are short (20–24 nt) noncoding RNAs that post-transcriptionally regulate gene expression in multicellular organisms by influencing mRNA stability and translation. They are transcribed by RNA polymerase II as capped, polyadenylated primary transcripts (pri-miRNAs), which can be protein-coding or noncoding. The primary transcript is cleaved by the RNase III enzyme Drosha to generate an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cut by cytoplasmic Dicer to produce mature miRNA and antisense miRNA star (miRNA*) products. Mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most often causes translational inhibition or destabilization of the target mRNA. [provided by RefSeq, Sep 2009]

OMIM entry for MIRLET7A2     Wikipedia entry for MIRLET7A2

Gene Sequence

Gene Sequence

Nucleotide sequence of MIRLET7A2:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIRLET7A2:           Showing partial SNPs
rs482869       rs516648       rs517593       rs547008       rs556503       rs562052       rs629367       rs685604       rs685925       rs692823       rs693120       rs1143770       rs1783877       rs5795312       rs5795314       rs11218535       rs11218536      

Gene Expression

Gene Expression

Tissue expression of MIRLET7A2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIRLET7A2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIRLET7A2:

Related microRNA

Related microRNA

microRNAs potentially regulating MIRLET7A2:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of ovary 0.002638474 2 0 BeFree_GAD
Stomach Carcinoma 0.000271442 1 1 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Gastritis, Atrophic 0.000271442 1 1 BeFree
Malignant neoplasm of stomach 0.000271442 1 1 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Medulloblastoma 0.000271442 1 0 BeFree
Cytogenetically normal acute myeloid leukemia 0.000271442 1 0 BeFree

Related Publications

Related Publications

Strong Association Between MiRNA Gene Variants and Type 2 Diabetes Mellitus in a Caucasian Population.
Manthou E, Tsekmekidou X, Tsetsos F, Koufakis T, Grammatiki M, Rakintzi P, Melidou E, Karaliolios G, Paschou P, Papanas N, Kotsa K Int J Mol Sci IF: 3.226 2025-10-28
Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue.
Ribeiro Ricardo, Monteiro Cátia, Catalán Victoria, Hu Pingzhao, Cunha Virgínia, Rodríguez Amaia, Gómez-Ambrosi Javier, Fraga Avelino, Príncipe Paulo, Lobato Carlos, Lobo Francisco, Morais António, Silva Vitor, Sanches-Magalhães José, Oliveira Jorge, Pina Francisco, Lopes Carlos, Medeiros Rui, Frühbeck Gema BMC Med IF: 8.7 2013-03-06

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