MIRLET7A3 (microRNA let-7a-3)

Gene Basic Information

Gene Basic Information

symbol:
MIRLET7A3
locus group:
non-coding RNA
location:
22q13.31
gene_family:
MicroRNAs
alias symbol:
hsa-let-7a-3
alias name:
None
entrez id:
406883
ensembl gene id:
ENSG00000283990
ucsc gene id:
uc021wrn.2
refseq accession:
NR_029478
hgnc_id:
HGNC:31478
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

22q13.31

Gene Summary

Gene Summary

ChineseEnglish

MicroRNAs (miRNAs) are short (20–24 nucleotide) noncoding RNAs that participate in post-transcriptional regulation of gene expression by affecting mRNA stability and translation in multicellular organisms. miRNAs are transcribed by RNA polymerase II as capped and polyadenylated primary transcripts (pri-miRNAs), which may be protein-coding or noncoding. The primary transcript is cleaved by Drosha RNase III to produce an approximately 70-nucleotide stem-loop precursor miRNA (pre-miRNA), which is further cleaved by cytoplasmic Dicer to yield mature miRNA and antisense miRNA star (miRNA*) products. Mature miRNA is incorporated into the RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most often causes translation inhibition or destabilization of the target mRNA. RefSeq represents the predicted microRNA stem-loop. [Provided by RefSeq, Sep 2009]

OMIM entry for MIRLET7A3     Wikipedia entry for MIRLET7A3

Gene Sequence

Gene Sequence

Nucleotide sequence of MIRLET7A3:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIRLET7A3:           Showing partial SNPs
rs731085       rs738559       rs738560       rs6008582       rs7288847       rs9616142       rs9616144       rs9616145       rs9616146       rs9616147       rs9627620       rs11090910       rs11090911       rs11090912       rs73886707       rs74904937       rs79015526      

Gene Expression

Gene Expression

Tissue expression of MIRLET7A3:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAGGTAGTAGGTTGTATAGTTTGG
58
GCCACTTCAGGAAAGACAG
59
AGGTAGTAGGTTGTATAGTTTGGG
60
GCCACTTCAGGAAAGACAG
59
GGTAGTAGGTTGTATAGTTTGGG
58
GCCACTTCAGGAAAGACAG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIRLET7A3 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIRLET7A3:

Related microRNA

Related microRNA

microRNAs potentially regulating MIRLET7A3:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of ovary 0.002909916 3 0 BeFree_GAD
ovarian neoplasm 0.00272435 1 0 LHGDN
Leukemia, Myelocytic, Acute 0.000542884 2 0 BeFree
Ovarian Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree

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